T cell responses to SARS-CoV-2 spike cross-recognize Omicron.
T cell responses to SARS-CoV-2 spike cross-recognize Omicron.
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DOI：
10.1038/s41586-022-04460-3
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发表时间：
2022-03
期刊：
影响因子：
64.8
通讯作者：
Riou C
中科院分区：
文献类型：
--
作者：
Keeton R;Tincho MB;Ngomti A;Baguma R;Benede N;Suzuki A;Khan K;Cele S;Bernstein M;Karim F;Madzorera SV;Moyo-Gwete T;Mennen M;Skelem S;Adriaanse M;Mutithu D;Aremu O;Stek C;du Bruyn E;Van Der Mescht MA;de Beer Z;de Villiers TR;Bodenstein A;van den Berg G;Mendes A;Strydom A;Venter M;Giandhari J;Naidoo Y;Pillay S;Tegally H;Grifoni A;Weiskopf D;Sette A;Wilkinson RJ;de Oliveira T;Bekker LG;Gray G;Ueckermann V;Rossouw T;Boswell MT;Bhiman JN;Moore PL;Sigal A;Ntusi NAB;Burgers WA;Riou C
SARS-CoV-2 Omicron变种(B.1.1.529)具有多个尖峰蛋白突变，这些突变有助于病毒逃避抗体中和，并降低疫苗对感染的保护。适应性反应的其他成分，如T细胞，在多大程度上仍可能针对奥美康，并有助于保护免受严重后果的影响，目前尚不清楚。在这里，我们评估了接种Ad26.CoV2.S或BNT162b2疫苗的参与者或未接种恢复期新冠肺炎患者(n = 70)的T细胞对Omicron Spike蛋白的反应能力。在研究组中，70%至80%的CD4+和CD8+T细胞对SPEKE的反应保持不变。此外，尽管奥米克隆存在相当多的突变，但Beta(B.1.351)和Delta(B.1.617.2)变体的奥米克隆交叉反应T细胞的大小是相似的。在奥米克龙感染住院患者(n = 19)中，T细胞对祖先棘波、核衣壳和膜蛋白的反应与以前以祖先、贝塔或Delta变异为主的患者(n = 49)相似。因此，尽管存在广泛的突变，降低了对奥美康中和抗体的易感性，但疫苗接种或感染引起的大多数T细胞反应都能交叉识别该变体。对奥美康保存良好的T细胞免疫是否有助于抵御严重新冠肺炎的保护，以及是否与南非和其他地方的早期临床观察有关，仍有待确定。在接种疫苗、感染和未接种疫苗的个体中，T细胞对SARS-CoV-2 Omicron变异株(B.1.1.529)刺突蛋白的应答与对祖先、贝塔(B.1.351)和Delta(B.1.617.2)刺突蛋白的应答基本相似。
The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations that contribute to viral escape from antibody neutralization and reduce vaccine protection from infection. The extent to which other components of the adaptive response such as T cells may still target Omicron and contribute to protection from severe outcomes is unknown. Here we assessed the ability of T cells to react to Omicron spike protein in participants who were vaccinated with Ad26.CoV2.S or BNT162b2, or unvaccinated convalescent COVID-19 patients (n = 70). Between 70% and 80% of the CD4+ and CD8+ T cell response to spike was maintained across study groups. Moreover, the magnitude of Omicron cross-reactive T cells was similar for Beta (B.1.351) and Delta (B.1.617.2) variants, despite Omicron harbouring considerably more mutations. In patients who were hospitalized with Omicron infections (n = 19), there were comparable T cell responses to ancestral spike, nucleocapsid and membrane proteins to those in patients hospitalized in previous waves dominated by the ancestral, Beta or Delta variants (n = 49). Thus, despite extensive mutations and reduced susceptibility to neutralizing antibodies of Omicron, the majority of T cell responses induced by vaccination or infection cross-recognize the variant. It remains to be determined whether well-preserved T cell immunity to Omicron contributes to protection from severe COVID-19 and is linked to early clinical observations from South Africa and elsewhere. T cell responses to spike protein from the SARS-CoV-2 Omicron variant (B.1.1.529) are broadly similar to the responses to ancestral, Beta (B.1.351) and Delta (B.1.617.2) spike protein in vaccinated, infected and unvaccinated individuals.
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CoVID-19疫苗或感染引起的SARS-COV-2 T细胞反应预计将保持对Omicron的稳健性。
DOI：
10.3390/v14010079
发表时间：
2022-01-02
期刊：
Viruses
影响因子：
--
作者：
Ahmed SF;Quadeer AA;McKay MR
通讯作者：
McKay MR
影响因子：
82.9
作者：
Gao Y;Cai C;Grifoni A;Müller TR;Niessl J;Olofsson A;Humbert M;Hansson L;Österborg A;Bergman P;Chen P;Olsson A;Sandberg JK;Weiskopf D;Price DA;Ljunggren HG;Karlsson AC;Sette A;Aleman S;Buggert M
通讯作者：
Buggert M
影响因子：
2.7
作者：
Kiecker, F;Streitz, M;Kern, F
通讯作者：
Kern, F
DOI：
10.1016/j.xcrm.2021.100354
发表时间：
2021-07-20
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Cohen KW;Linderman SL;Moodie Z;Czartoski J;Lai L;Mantus G;Norwood C;Nyhoff LE;Edara VV;Floyd K;De Rosa SC;Ahmed H;Whaley R;Patel SN;Prigmore B;Lemos MP;Davis CW;Furth S;O'Keefe JB;Gharpure MP;Gunisetty S;Stephens K;Antia R;Zarnitsyna VI;Stephens DS;Edupuganti S;Rouphael N;Anderson EJ;Mehta AK;Wrammert J;Suthar MS;Ahmed R;McElrath MJ
通讯作者：
McElrath MJ
影响因子：
64.5
作者：
Garcia-Beltran WF;St Denis KJ;Hoelzemer A;Lam EC;Nitido AD;Sheehan ML;Berrios C;Ofoman O;Chang CC;Hauser BM;Feldman J;Roederer AL;Gregory DJ;Poznansky MC;Schmidt AG;Iafrate AJ;Naranbhai V;Balazs AB
通讯作者：
Balazs AB