Go/No-Go task engagement enhances population representation of target stimuli in primary auditory cortex.
Go/No-Go task engagement enhances population representation of target stimuli in primary auditory cortex.
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DOI：
10.1038/s41467-018-04839-9
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发表时间：
2018-06-28
影响因子：
16.6
通讯作者：
Ostojic S
中科院分区：
文献类型：
--
作者：
Bagur S;Averseng M;Elgueda D;David S;Fritz J;Yin P;Shamma S;Boubenec Y;Ostojic S
初级感觉皮层通常被认为提取和表征刺激特征，而联想和高阶区域被认为携带有关刺激意义的信息。在这里，我们表明，这些信息实际上可以在初级听觉皮层（A1）的神经元群体代码中找到。A1活动记录在清醒的雪貂，而他们要么被动地听或主动歧视刺激的范围内去/不去的范式，不同的声音和增援。人口层面的降维技术表明，任务参与诱导刺激编码从感官到行为驱动的代表性，特别是增强了目标刺激在所有的范例的转变。这种转变部分依赖于任务参与引起的自发活动的变化。总之，我们表明，A1人口活动具有很强的相似性，额叶皮层的反应。这些发现表明，初级感觉皮层在行为过程中提取任务相关信息的群体活动结构中实现了一个重要的变化。感觉区被认为处理刺激信息，而高级处理发生在联合皮层。在这里，作者报告说，在任务参与过程中，雪貂初级听觉皮层的群体活动从编码刺激特征转向检测行为相关的目标。
Primary sensory cortices are classically considered to extract and represent stimulus features, while association and higher-order areas are thought to carry information about stimulus meaning. Here we show that this information can in fact be found in the neuronal population code of the primary auditory cortex (A1). A1 activity was recorded in awake ferrets while they either passively listened or actively discriminated stimuli in a range of Go/No-Go paradigms, with different sounds and reinforcements. Population-level dimensionality reduction techniques reveal that task engagement induces a shift in stimulus encoding from a sensory to a behaviorally driven representation that specifically enhances the target stimulus in all paradigms. This shift partly relies on task-engagement-induced changes in spontaneous activity. Altogether, we show that A1 population activity bears strong similarities to frontal cortex responses. These findings indicate that primary sensory cortices implement a crucial change in the structure of population activity to extract task-relevant information during behavior. Sensory areas are thought to process stimulus information while higher-order processing occurs in association cortices. Here the authors report that during task engagement population activity in ferret primary auditory cortex shifts away from encoding stimulus features toward detection of the behaviourally relevant targets.
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影响因子：
16.2
作者：
Kajikawa Y;Schroeder CE
通讯作者：
Schroeder CE
影响因子：
3.5
作者：
Englitz, B.;David, S. V.;Shamma, S. A.
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通讯作者：
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影响因子：
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Fritz, Jonathan B.;David, Stephen V.;Radtke-Schuller, Susanne;Yin, Pingbo;Shamma, Shihab A.
通讯作者：
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