Role of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.
Role of ghrelin system in neuroprotection and cognitive functions: implications in Alzheimer's disease.
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DOI：
10.1016/j.peptides.2011.09.019
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发表时间：
2011-11
期刊：
影响因子：
3
通讯作者：
Castaño JP
中科院分区：
文献类型：
--
作者：
Gahete MD;Córdoba-Chacón J;Kineman RD;Luque RM;Castaño JP
阿尔茨海默病（Alzheimer's disease，AD）是一种多因素的进行性神经退行性疾病，其特征在于记忆丧失和认知缺陷，受代谢状态的强烈影响，其中先前已观察到神经肽/神经递质系统的损害。Ghrelin是一种在多种组织中产生的多功能激素，其与肥胖和代谢综合征的进展有关，但也与神经调节、神经保护以及记忆和学习过程有关。此外，生长素释放肽系统还以自分泌/旁分泌方式起作用，其中其大部分组分[生长素释放肽变体（天然生长素释放肽，In 2-生长素释放肽）、酰化酶（GOAT）和受体（GHS-R）]在中枢神经系统的不同区域中表达。尽管所有这些信息都强烈表明ghrelin系统与AD之间存在密切联系，可能具有病理生理学相关性，但很少有研究阐明这种关系。本文综述了ghrelin系统在神经保护、记忆巩固和学习中的作用，并讨论了其在AD中的作用及其在AD患者中的表达调控。
Alzheimer’s disease (AD) is a multifactorial progressive neurodegenerative disorder characterized by loss of memory and cognitive deficits, strongly influenced by the metabolic status, in which the impairment of neuropeptides/neurotransmitters systems has been previously observed. Ghrelin is a multifunctional hormone produced in a wide variety of tissues, which has been associated with the progression of obesity and metabolic syndrome, but has been also linked to neuromodulation, neuroprotection and memory and learning processes. In addition, ghrelin system also acts in an autocrine/paracrine fashion where the majority of its components [ghrelin variants (native ghrelin, In2-ghrelin), acylation enzymes (GOAT) and receptors (GHS-Rs)] are expressed in the different regions of central nervous system. In spite of all these pieces of information strongly suggesting a close association between ghrelin system and AD, which could be of pathophysiological relevance, few studies have been addressed to clarify this relationship. In this work, the role of ghrelin system in neuroprotection, memory consolidation and learning is reviewed, and its influence in AD, as well as the regulation of its expression in AD patients, is discussed.
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