Epigenetic mechanisms underlying learning and the inheritance of learned behaviors.
Epigenetic mechanisms underlying learning and the inheritance of learned behaviors.
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DOI：
10.1016/j.tins.2014.12.003
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发表时间：
2015-02
影响因子：
15.9
通讯作者：
Ressler KJ
中科院分区：
文献类型：
--
作者：
Dias BG;Maddox S;Klengel T;Ressler KJ
基因的表达和调控是生物体行为的重要雕塑家。表观遗传机制不是通过改变遗传字母表来调节基因表达，而是通过对与字母表相关的蛋白质进行化学修饰或对字母表本身进行甲基标记来调节基因表达。基因调控的表观遗传机制是环境刺激与基因型之间的重要桥梁。在这篇综述中，我们概述了在动物和人类基因表达调控的表观遗传机制。使用恐惧学习作为一个框架，然后我们描绘了这样的机制是如何学习和压力反应的基础。最后，我们讨论了表观遗传机制如何告知我们越来越多的行为特征的跨代遗传。
Gene expression and regulation is an important sculptor of the behavior of organisms. Epigenetic mechanisms regulate gene expression not by altering the genetic alphabet but rather by the addition of chemical modifications to proteins associated with the alphabet or of methyl marks to the alphabet itself. Being dynamic, epigenetic mechanisms of gene regulation serve as an important bridge between environmental stimuli and genotype. In this review, we outline epigenetic mechanisms by which gene expression is regulated in animals and humans. Using fear learning as a framework, we then delineate how such mechanisms underlie learning and stress responsiveness. Finally, we discuss how epigenetic mechanisms might inform us about the transgenerational inheritance of behavioral traits that are being increasingly reported.
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影响因子：
16.2
作者：
Dias, Brian George;Goodman, Jared Vega;Ahluwalia, Ranbir;Easton, Audrey Elizabeth;Andero, Rauel;Ressler, Kerry James
通讯作者：
Ressler, Kerry James
影响因子：
25
作者：
Gapp, Katharina;Jawaid, Ali;Sarkies, Peter;Bohacek, Johannes;Pelczar, Pawel;Prados, Julien;Farinelli, Laurent;Miska, Eric;Mansuy, Isabelle M.
通讯作者：
Mansuy, Isabelle M.
影响因子：
3.9
作者：
Brunner AM;Nanni P;Mansuy IM
通讯作者：
Mansuy IM
影响因子：
16.8
作者：
Brykczynska, Urszula;Hisano, Mizue;Peters, Antoine H. F. M.
通讯作者：
Peters, Antoine H. F. M.
影响因子：
10.6
作者：
Champagne, Frances A.;Meaney, Michael J.
通讯作者：
Meaney, Michael J.