Epidemiologic Evidence of and Potential Mechanisms by Which Second-Hand Smoke Causes Predisposition to Latent and Active Tuberculosis.

Epidemiologic Evidence of and Potential Mechanisms by Which Second-Hand Smoke Causes Predisposition to Latent and Active Tuberculosis.
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DOI:
10.4110/in.2018.18.e22
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发表时间:
2018-06
期刊:
影响因子:
6
通讯作者:
Chan ED
Chan ED
中科院分区:
医学3区
文献类型:
--
作者:
Bai X;Aerts SL;Verma D;Ordway DJ;Chan ED

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许多研究将吸烟(CS)暴露与结核病(TB)感染和疾病联系起来,尽管很少有人研究二手烟(SHS)暴露。我们的目标是回顾SHS和TB之间的流行病学联系,以及总结SHS和直接CS对与TB相关的各种免疫细胞的影响。使用“结核病”和“香烟”、“烟草”或“二手烟”等关键词进行PubMed检索。审查了相关论文的参考书目,以寻找其他相关出版物。相对较少的研究将SHS暴露与结核感染和活动性疾病联系起来。SHS和直接CS都可以改变宿主免疫力的各个组成部分,从而增加对结核病的易感性。虽然这两种疾病的流行病学联系是强有力的,但需要更明确的机制研究来证明SHS和直接CS实际上会增加对结核病的易感性。
Many studies have linked cigarette smoke (CS) exposure and tuberculosis (TB) infection and disease although much fewer have studied second-hand smoke (SHS) exposure. Our goal is to review the epidemiologic link between SHS and TB as well as to summarize the effects SHS and direct CS on various immune cells relevant for TB. PubMed searches were performed using the key words “tuberculosis” with “cigarette,” “tobacco,” or “second-hand smoke.” The bibliography of relevant papers were examined for additional relevant publications. Relatively few studies associate SHS exposure with TB infection and active disease. Both SHS and direct CS can alter various components of host immunity resulting in increased vulnerability to TB. While the epidemiologic link of these 2 health maladies is robust, more definitive, mechanistic studies are required to prove that SHS and direct CS actually cause increased susceptibility to TB.
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