Caspase-Independent Regulated Necrosis Pathways as Potential Targets in Cancer Management.
Caspase-Independent Regulated Necrosis Pathways as Potential Targets in Cancer Management.
复制标题
不依赖半胱天冬酶的坏死调节途径作为癌症治疗的潜在目标
DOI：
10.3389/fonc.2020.616952
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发表时间：
2020
影响因子：
4.7
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Lou J;Zhou Y;Feng Z;Ma M;Yao Y;Wang Y;Deng Y;Wu Y
调节性坏死是一种新出现的不依赖于半胱天冬酶的细胞死亡类型。近年来，随着生物化学和遗传学领域对调控性坏死的研究不断深入，其分子机制和信号通路逐渐被人们所了解。目前，调节性坏死与肿瘤的发生、发展密切相关，包括坏死性凋亡、铁凋亡、凋亡抑制、焦凋亡等;越来越多的证据表明，各种化合物都可以通过诱导肿瘤细胞发生调节性坏死而发挥抗癌作用，这表明非半胱天冬酶依赖的调节性坏死途径是肿瘤治疗的潜在靶点。本文就多种调控性坏死的分子机制和信号通路进行综述。我们还详细阐述了它们在肿瘤发生中的作用，并讨论了如何将每种调节性坏死途径作为治疗靶点。
Regulated necrosis is an emerging type of cell death independent of caspase. Recently, with increasing findings of regulated necrosis in the field of biochemistry and genetics, the underlying molecular mechanisms and signaling pathways of regulated necrosis are gradually understood. Nowadays, there are several modes of regulated necrosis that are tightly related to cancer initiation and development, including necroptosis, ferroptosis, parthanatos, pyroptosis, and so on. What’s more, accumulating evidence shows that various compounds can exhibit the anti-cancer effect via inducing regulated necrosis in cancer cells, which indicates that caspase-independent regulated necrosis pathways are potential targets in cancer management. In this review, we expand the molecular mechanisms as well as signaling pathways of multiple modes of regulated necrosis. We also elaborate on the roles they play in tumorigenesis and discuss how each of the regulated necrosis pathways could be therapeutically targeted.
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DOI：
10.1016/0006-291x(77)90623-4
发表时间：
1977-01-01
影响因子：
3.1
作者：
BANNAI, S;TSUKEDA, H;OKUMURA, H
通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
16
作者：
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通讯作者：
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DOI：
10.1073/pnas.0606526103
发表时间：
2006-11-28
影响因子：
11.1
作者：
Andrabi, Shaida A.;Kim, No Soo;Dawson, Ted M.
通讯作者：
Dawson, Ted M.
影响因子：
7.2
作者：
Chen, Liping;Weng, Bixia;Wu, Jianzhang
通讯作者：
Wu, Jianzhang