Functional and pathological characteristics of reversible remodeling in a canine right ventricle in response to volume overloading and volume unloading.
Functional and pathological characteristics of reversible remodeling in a canine right ventricle in response to volume overloading and volume unloading.
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DOI：
10.1007/s00595-014-0847-y
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发表时间：
2014-10
期刊：
影响因子：
2.5
通讯作者：
Sawa, Yoshiki
中科院分区：
文献类型：
--
作者：
Ishimaru, Kazuhiko;Miyagawa, Shigeru;Fukushima, Satsuki;Ide, Haruki;Hoashi, Takaya;Shibuya, Toshiharu;Ueno, Takayoshi;Sawa, Yoshiki
由于肺功能不全相关的容量过载（VOL），接受右心室（RV）流出增强术的患者不可避免地会发生右心室重构。然而，这种重塑的可逆性尚不完全清楚。本研究的目的是建立VOL和卸载动物模型，以表征RV重塑的功能、病理特征和可逆性。在比格犬体内建立直接肺动脉旁路（PA），成功诱导VOL-RV 12周。无手术相关死亡（n = 8）。通过三维超声心动图和心导管检查，右心室出现了典型的vol相关重构的功能特征，如舒张末期/收缩期容积和收缩期末期压力显著增加，射血分数显著降低。RV表现出典型的心肌细胞重塑、微结构紊乱和/或线粒体结构/功能恶化的病理症状。与假手术相比，通过分割RV-PA旁路进行的体积卸载在4周内逆转了收缩末期/舒张末期体积的增加（各n = 4）。此外，旁路分割也逆转了VOL-RV的病理改变。在犬的RV- pa直接旁路移植术中，可以重现产生典型的RV重塑功能和病理特征的VOL-RV。由VOL引起的RV重构在功能和病理上通过旁路分流卸体积逆转。
Patients who undergo right ventricular (RV) outflow augmentation inevitably develop RV remodeling due to pulmonary insufficiency-related volume overload (VOL). However, the reversibility of this remodeling is not fully understood. The goal of this study was to establish an animal model of VOL and unloading to characterize the functional and pathological characteristics and reversibility of RV remodeling. VOL-RV was successfully induced by establishing direct RV-pulmonary artery (PA) bypass for 12 weeks in beagle canines. There were no procedure-related mortalities (n = 8). The RV developed typical functional features of VOL-related remodeling, such as a significant increase in end-diastolic/systolic volume and end-systolic pressure and a significant reduction in ejection fraction at 12 weeks, as assessed by three-dimensional echocardiography and cardiac catheterization. The RV developed typical pathological signs of remodeling, microstructural disorganization of cardiomyocytes, and/or structural/functional deterioration of the mitochondria. Volume unloading by division of the RV-PA bypass reversed the increase in the end-systolic/diastolic volume over 4 weeks when compared with a sham operation (n = 4 each). In addition, the bypass division also reversed the pathological changes seen in VOL-RV. VOL-RV that yielded typical functional and pathological features of RV remodeling was reproducibly achieved by direct RV-PA bypass in canines. The RV remodeling due to VOL was functionally and pathologically reversed by volume unloading via the bypass division.
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影响因子：
18.2
作者：
De Stefano, Laercio Martins;Matsubara, Luiz Shiguero;Matsubara, Beatriz Bojikian
通讯作者：
Matsubara, Beatriz Bojikian
DOI：
10.1016/j.jtcvs.2009.02.018
发表时间：
2009-08-01
影响因子：
6
作者：
Hoashi, Takaya;Matsumiya, Goro;Sawa, Yoshiki
通讯作者：
Sawa, Yoshiki
影响因子：
4.3
作者：
Oliver-Dussault, Christelle;Ascah, Alexis;Deschepper, Christian F.
通讯作者：
Deschepper, Christian F.
影响因子：
--
作者：
Adamson, Louise;Vohra, Hunaid A;Haw, Marcus P
通讯作者：
Haw, Marcus P
DOI：
10.1152/ajpheart.1998.274.5.h1429
发表时间：
1998-05-01
影响因子：
4.8
作者：
Sato, T;Shishido, T;Sunagawa, K
通讯作者：
Sunagawa, K