Effect of Post-Polyketide Synthase Modification Groups on Property and Activity of Polyene Macrolides.
Effect of Post-Polyketide Synthase Modification Groups on Property and Activity of Polyene Macrolides.
复制标题
聚酮合酶后修饰基团对多烯大环内酯性质和活性的影响
DOI：
10.3390/antibiotics12010119
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发表时间：
2023-01-08
影响因子：
4.8
通讯作者：
Cui, Hao
中科院分区：
文献类型：
--
作者：
Qiao, Liqin;Dong, Yao;Zhou, Hongli;Cui, Hao
土壤放线菌产生的天然产物多烯大环内酯类化合物的生物合成已经得到了广泛的研究，最近的研究集中在多烯大环内酯类化合物的后聚酮合成酶(PKS)修饰对其毒性、水溶性和抗真菌活性的影响。例如，在后PKS修饰步骤中产生的糖基、羧基和羟基或环氧基之间存在相互作用；在菌胺上的羧酸盐和铵之间会形成盐桥；在菌胺上的羟基和羟基之间会形成水桥。这些相互作用将影响它们的水溶性和底物识别专一性。本文综述了与这些PKS后修饰基团相关的研究，并讨论了在修饰这些PKS后修饰基团时可能遇到的一些基因工程操作问题和解决方案。此外，本综述还为多烯大环内酯类抗生素的结构研究提供了基础，有助于全面、系统地认识多烯大环内酯类抗生素，从而鼓励研究人员开发具有更高治疗指数和医学价值的新型抗真菌药物。
The biosynthesis of polyene macrolides, which are natural products produced by soil actinomycetes, have been extensively explored, and recent studies have focused on the effects of post–polyketide synthase (PKS) modifications to polyene macrolides on toxicity, water solubility, and antifungal activity. For example, there are interactions between glycosyl, carboxyl, and hydroxyl or epoxy groups generated in the post-PKS modification steps; salt bridges will be formed between carboxylate and ammonium on the mycosamine; and water bridges will be formed between hydroxy and hydroxyl on mycosamine. These interactions will affect their water solubility and substrate-recognition specificity. This review summarizes research related to these post-PKS modification groups and discusses some genetic engineering operation problems and solutions that may be encountered when modifying these post-PKS modification groups. In addition, this review provides a basis for the structural research of polyene macrolide antibiotics and contributes to comprehensive and systematic knowledge, and it may thus encourage researchers to develop novel antifungal drugs with higher therapeutic indexes and medical values.
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影响因子：
14.8
作者：
Anderson TM;Clay MC;Cioffi AG;Diaz KA;Hisao GS;Tuttle MD;Nieuwkoop AJ;Comellas G;Maryum N;Wang S;Uno BE;Wildeman EL;Gonen T;Rienstra CM;Burke MD
通讯作者：
Burke MD
影响因子：
3.3
作者：
Gagos, Mariusz;Kaminski, Daniel;Mackowski, Sebastian
通讯作者：
Mackowski, Sebastian
影响因子：
3
作者：
Du, Yi-Ling;Chen, Shi-Fei;Li, Yong-Quan
通讯作者：
Li, Yong-Quan
影响因子：
2.8
作者：
Campelo, AB;Gil, JA
通讯作者：
Gil, JA
DOI：
10.1007/s10295-009-0629-5
发表时间：
2009-11-01
影响因子：
3.4
作者：
Kim, Byung-Gyun;Lee, Mi-Jin;Kim, Eung-Soo
通讯作者：
Kim, Eung-Soo