The role of M1 and M2 macrophages in prostate cancer in relation to extracapsular tumor extension and biochemical recurrence after radical prostatectomy.
The role of M1 and M2 macrophages in prostate cancer in relation to extracapsular tumor extension and biochemical recurrence after radical prostatectomy.
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DOI：
10.1155/2014/486798
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发表时间：
2014
影响因子：
--
通讯作者：
Serni S
中科院分区：
文献类型：
--
作者：
Lanciotti M;Masieri L;Raspollini MR;Minervini A;Mari A;Comito G;Giannoni E;Carini M;Chiarugi P;Serni S
介绍。我们工作的目的是调查 M1 和 M2 巨噬细胞表型的发生与前列腺癌之间的因果关系，及其与肿瘤扩展 (ECE) 和生化复发 (BR) 的相关性。 患者和方法。前瞻性收集了 93 名接受根治性前列腺切除术治疗的患者的临床和病理数据。通过单变量和多变量分析评估常用变量的相关性。还通过 Kaplan-Meier 生存分析评估了 M1 和 M2 发生与 BR 之间的关系。 结果。最重要的是，63.4% 的人有 M2 患病率。 M1 在 OC 疾病中更常见，而 M2 在 ECE 中更常见。在单变量分析中，活检和病理学 GS 和 M2 与 ECE 具有统计学相关性。仅病理学 GS 和 M2 被证实与 ECE 相关。根据巨噬细胞密度，BCR游离生存曲线呈现出统计学上显着的差异。当我们对 M1 和 M2 人群进行分层时，我们没有发现曲线之间存在任何统计差异。在单变量分析中，GS、pTNM 和阳性切缘是 BCR 的显着预测因子，而 M1 和 M2 没有达到统计学显着性。在多变量分析中，只有 GS 和病理分期是 BR 的独立预测因子。 结论。在我们的研究中，M 计数密度较高的患者预后不良； M2 表型与 ECE 显着相关。
Introduction. The aim of our work was to investigate the causal connection between M1 and M2 macrophage phenotypes occurrence and prostate cancer, their correlation with tumor extension (ECE), and biochemical recurrence (BR). Patient and Methods. Clinical and pathological data were prospectively gathered from 93 patients treated with radical prostatectomy. Correlations of commonly used variables were evaluated with uni- and multivariate analysis. The relationship between M1 and M2 occurrence and BR was also assessed with Kaplan-Meier survival analysis. Results. Above all in 63.4% there was a M2 prevalence. M1 occurred more frequently in OC disease, while M2 was more represented in ECE. At univariate analysis biopsy and pathologic GS and M2 were statistically correlated with ECE. Only pathologic GS and M2 confirmed to be correlated with ECE. According to macrophage density BCR free survival curves presented a statistically significant difference. When we stratified our population for M1 and M2,we did not find any statistical difference among curves. At univariate analysis GS, pTNM, and positive margins resulted to be significant predictors of BCR, while M1 and M2 did not achieve the statistical significance. At multivariate analysis, only GS and pathologic stage were independent predictors of BR. Conclusion. In our study patients with higher density of M count were associated with poor prognosis; M2 phenotype was significantly associated with ECE.
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