Outer membrane vesicles of Porphyromonas gingivalis: Novel communication tool and strategy.
Outer membrane vesicles of Porphyromonas gingivalis: Novel communication tool and strategy.
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DOI：
10.1016/j.jdsr.2021.07.003
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Guo J
中科院分区：
文献类型：
--
作者：
Okamura H;Hirota K;Yoshida K;Weng Y;He Y;Shiotsu N;Ikegame M;Uchida-Fukuhara Y;Tanai A;Guo J
细胞外囊泡（EV）已被认为是细胞通信的通用方法，并且据报道在细菌、古细菌和真核生物中产生。细菌EV通常被称为“外膜囊泡”（OMV），因为它们是革兰氏阴性细菌（如牙龈卟啉单胞菌（P. gingivalis））外膜受控起泡的结果。细菌EV是天然信使，涉及存在于微生物群中的微生物群体之间的种内和种间细胞间通信。细菌可以将它们的病原体合并到OMV中; OMV的含量不同，取决于细菌的类型。不同类型的OMV的产生可以由不同的因子和途径介导。最近的一项研究强调了OMV携带与免疫调节有关的关键分子的能力，如今，它们被认为是从细菌到宿主之间传递信息的一种方式，反之亦然。本文就牙龈卟啉单胞菌OMV的产生、特征、含量及其在宿主细胞信号转导和系统性疾病中的作用进行综述。本文还对牙龈卟啉单胞菌OMV在生物体内的作用进行了综述。
Extracellular vesicles (EVs) have been recognized as a universal method of cellular communications and are reportedly produced in bacteria, archaea, and eukaryotes. Bacterial EVs are often called “Outer Membrane Vesicles” (OMVs) as they were the result of a controlled blebbing of the outer membrane of gram-negative bacteria such as Porphyromonas gingivalis (P. gingivalis). Bacterial EVs are natural messengers, implicated in intra- and inter-species cell-to-cell communication among microorganism populations present in microbiota. Bacteria can incorporate their pathogens into OMVs; the content of OMVs differs, depending on the type of bacteria. The production of distinct types of OMVs can be mediated by different factors and routes. A recent study highlighted OMVs ability to carry crucial molecules implicated in immune modulation, and, nowadays, they are considered as a way to communicate and transfer messages from the bacteria to the host and vice versa. This review article focuses on the current understanding of OMVs produced from major oral bacteria, P. gingivalis: generation, characteristics, and contents as well as the involvement in signal transduction of host cells and systemic diseases. Our recent study regarding the action of P. gingivalis OMVs in the living body is also summarized.
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影响因子：
3.1
作者：
GRENIER, D;BELANGER, M
通讯作者：
BELANGER, M
影响因子：
5.2
作者：
Gabarrini G;Palma Medina LM;Stobernack T;Prins RC;du Teil Espina M;Kuipers J;Chlebowicz MA;Rossen JWA;van Winkelhoff AJ;van Dijl JM
通讯作者：
van Dijl JM
影响因子：
4.6
作者：
Dong XH;Ho MH;Liu B;Hildreth J;Dash C;Goodwin JS;Balasubramaniam M;Chen CH;Xie H
通讯作者：
Xie H
影响因子：
7.6
作者：
Choi, J. -W.;Kim, S. -C.;Lee, H. -J.
通讯作者：
Lee, H. -J.
影响因子：
--
作者：
GRENIER, D;BERTRAND, J;MAYRAND, D
通讯作者：
MAYRAND, D