Comparative effectiveness of PEEK rods versus titanium alloy rods in cervical fusion in a new sheep model
Comparative effectiveness of PEEK rods versus titanium alloy rods in cervical fusion in a new sheep model
复制标题
PEEK 棒与钛合金棒在新绵羊模型颈椎融合中的效果比较
DOI：
10.1007/s00586-020-06307-9
复制
发表时间：
2020-02
影响因子：
2.8
通讯作者：
Guo Zheng
中科院分区：
文献类型：
--
作者：
Wu Jie;Shi Lei;Pei Yanjun;Yang Di;Gao Peng;Xiao Xin;Guo Shuo;Li Minghui;Li Xiaokang;Guo Zheng
背景钛基椎弓根螺钉和杆器械可以为脊柱融合产生令人满意的强度和刚度。然而，钛棒产生的过度刚度可能会导致应力屏蔽。因此，低弹性模量的聚醚醚酮（PEEK）棒被引入作为钛棒的替代品。本文的目的是比较PEEK棒与钛合金棒在新型绵羊模型中进行前路脊柱融合的效果。方法本研究创新性地采用绵羊颈椎前后路融合模型。将24只羊随机分为对照组和治疗组，分别采用钛棒或PEEK棒进行颈椎前后路固定。然后，采集手术节段，通过X射线、显微CT和组织学检查评估骨融合的效率。结果在研究过程中未发现与固定相关的并发症。 X射线结果显示，术后12周，PEEK棒组的脊柱融合力强于钛棒组，两组均在术后24周进行骨融合。显微CT结果显示，与钛棒固定相比，PEEK棒固定在术后早期（12周）实现了更好的骨长入（骨体积分数（BVF）：20.26±4.36% vs 14.48±3.49%，p<0.05）。组织学分析也发现同样的趋势，实验组矿化骨分数（21.01±3.48%）显着高于对照组（16.73±2.95%）。此外，实验组在术后早期12周时发现更好的骨整合（骨附着（BA）：16.22±3.24% vs 11.67±3.63%，p<0.05）。然而，术后24周时没有显着差异。结论PEEK棒可以安全地用于绵羊颈椎前后路固定模型。与传统的钛棒相比，PEEK 棒组中发现了更早、更明显的骨融合。图文摘要这些幻灯片可以在电子补充材料下检索。
BackgroundPedicle screw and rod instrumentation based on titanium can produce satisfying strength and stiffness for spinal fusion. However, excessive stiffness produced by titanium rods may cause stress shielding. Thus, polyetheretherketone (PEEK) rods with a low modulus of elasticity were introduced as substitutes for titanium rods. The purpose of this paper is to compare the effectiveness of PEEK rods versus titanium alloy rods in anterior spinal fusion with a new sheep model.MethodsSheep models of anterior–posterior cervical fusion were innovatively adopted in our study. Twenty-four sheep were randomly divided into a control group and a treatment group that received anterior–posterior cervical fixation with titanium rods or PEEK rods, respectively. Then, surgical segments were harvested and assessed by X-ray, micro-CT and histological examination to evaluate the efficiency of bone fusion.ResultsNo complications related to fixation were found during the research process. The results of the X-ray showed a stronger spinal fusion in the PEEK rod groups than in the titanium rod group at 12 weeks postoperatively, and both groups underwent bone fusion at 24 weeks postoperatively. The results of micro-CT showed that fixation with PEEK rods achieved better bone ingrowth at an early postoperative stage (12 weeks) compared to fixation with titanium rods (bone volume fraction (BVF): 20.26 ± 4.36% vs 14.48 ± 3.49%,p< 0.05). The same trend was detected in the histological analysis, where the mineralized bone fraction in the experiment group (21.01 ± 3.48%) was significantly higher than that in the control group (16.73 ± 2.95%). In addition, better osseointegration was found in the experiment group at the early postoperative stage at 12 weeks (bone apposition (BA): 16.22 ± 3.24% vs 11.67 ± 3.63%,p< 0.05). However, there were no significant differences at 24 weeks postoperatively.ConclusionPEEK rods can be used safely in a sheep model of anterior–posterior cervical fixation. Compared to traditional titanium rods, earlier and more evident bone fusion was found in the PEEK rods group.Graphic abstractThese slides can be retrieved under Electronic Supplementary Material.
登录
查看更多内容
DOI：
10.1016/j.fjmd.2013.04.003
发表时间：
2013-05
期刊：
Formosan Journal of Musculoskeletal Disorders
影响因子：
--
作者：
Ting-Kuo Chang;Chang-Hung Huang;Yueh-Ching Liu;Wen-chuan Chen;Colin Mcclean;Yu-Shu Lai;Cheng-Kung Cheng-Cheng-Kung-Cheng-3453495
通讯作者：
Ting-Kuo Chang;Chang-Hung Huang;Yueh-Ching Liu;Wen-chuan Chen;Colin Mcclean;Yu-Shu Lai;Cheng-Kung Cheng-Cheng-Kung-Cheng-3453495
影响因子：
2.2
作者：
Jin A Choi;Hyun-Jin Jin-Hyun-Jin-Jin-2256478452;Samhyun Jung;Eunkyung Yang;Jun-Sub Choi;So-Hyang Chung;Choun-Ki Joo
通讯作者：
Jin A Choi;Hyun-Jin Jin-Hyun-Jin-Jin-2256478452;Samhyun Jung;Eunkyung Yang;Jun-Sub Choi;So-Hyang Chung;Choun-Ki Joo
影响因子：
3.9
作者：
Xiaolei Zhang;K. Vandamme;A. Torcasio;Toru Ogawa;G. H. van Lenthe;I. Naert;J. Duyck
通讯作者：
Xiaolei Zhang;K. Vandamme;A. Torcasio;Toru Ogawa;G. H. van Lenthe;I. Naert;J. Duyck
影响因子：
2.8
作者：
Lehmann, W.;Ushmaev, A.;Briem, D.
通讯作者：
Briem, D.
影响因子：
--
作者：
Nicole A DeVries Watson;Anup A. Gandhi;D. Fredericks;Joseph D. Smucker;N. Grosland
通讯作者：
Nicole A DeVries Watson;Anup A. Gandhi;D. Fredericks;Joseph D. Smucker;N. Grosland