Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain.
Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain.
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DOI：
10.1007/s11916-008-0057-7
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发表时间：
2008-10
影响因子：
3.7
通讯作者：
Sluka, Kathleen A.
中科院分区：
文献类型：
--
作者：
DeSantana, Josimari M.;Sluka, Kathleen A.
慢性广泛性疼痛(CWP)，如纤维肌痛和肌筋膜综合征，其特征是全身疼痛、压痛、晨僵、睡眠障碍和明显的疲劳。然而，煤工尘肺的病理生理学机制仍不清楚。许多假说被认为是CWP的潜在病理生理学机制：肌肉功能障碍/缺血、中枢敏感化和内源性疼痛调节系统缺陷。本文综述了目前和正在出现的关于慢性广泛性肌肉骨骼疼痛的病理生理学和神经生物学的文献。广泛的肌肉骨骼疼痛会导致人类受试者和动物模型的中枢神经系统发生变化。这些变化可能反映了脊髓上痛觉调制的变化，包括兴奋性调制通路的增加和抑制性调制通路的减少。这些兴奋和抑制的变化可能驱动脊髓中观察到的变化，导致中枢敏感化，以及随之而来的疼痛和痛敏。
Chronic widespread pain (CWP) conditions such as fibromyalgia and myofascial syndromes are characterized by generalized pain, tenderness, morning stiffness, disturbed sleep, and pronounced fatigue. However, CWP pathophysiology is still unclear. A number of hypotheses have been proposed as the underlying pathophysiology of CWP: muscular dysfunction/ischemia, central sensitization, and a deficit in endogenous pain-modulating systems. This article reviews the current and emerging literature about the pathophysiology and neurobiology of chronic widespread musculoskeletal pain. Widespread musculoskeletal pain results in changes in the central nervous system in human subjects and animal models. These changes likely reflect alterations in supraspinal modulation of nociception, and include increases in excitatory and decreases in inhibitory modulation pathways. These alterations in excitation and inhibition likely drive changes observed in the spinal cord to result in central sensitization, and the consequent pain and hyperalgesia.
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影响因子：
2.5
作者：
Bement, Marie K. Hoeger;Sluka, Kathleen A.
通讯作者：
Sluka, Kathleen A.
影响因子：
2.5
作者：
Dolan, S;Nolan, AM
通讯作者：
Nolan, AM
影响因子：
2.9
作者：
Nagano, M;Suzuki, H
通讯作者：
Suzuki, H
影响因子：
7.4
作者：
Price, DD;Staud, R;Vierck, CJ
通讯作者：
Vierck, CJ
DOI：
10.1073/pnas.122245999
发表时间：
2002-06-25
影响因子：
11.1
作者：
Chen, CC;Zimmer, A;Zimmer, A
通讯作者：
Zimmer, A