Rewarding and aversive effects of ethanol in High Drinking in the Dark selectively bred mice.
Rewarding and aversive effects of ethanol in High Drinking in the Dark selectively bred mice.
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DOI：
10.1111/adb.12079
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发表时间：
2015-01
影响因子：
3.4
通讯作者：
Crabbe JC
中科院分区：
文献类型：
--
作者：
Barkley-Levenson AM;Cunningham CL;Smitasin PJ;Crabbe JC
酒精的摄入既有有益的影响，也有有害的影响。基因上倾向于酗酒的动物对酒精的不良影响的敏感性降低，在某些情况下，对酒精的有益影响的敏感性增加。目前的研究测试了夜间高饮酒量（HDID）选择的品系，这是一种饮酒中毒的遗传模型，以确定这些小鼠的摄入量是否与对酒精厌恶或奖励的敏感性有关。来自第一和第二重复系（分别为HDID-1和HDID-2）的雄性HDID小鼠以及来自异质祖对照群体（HS/Npt，或HS）的小鼠被训练为对使用2剂量酒精、氯化锂（LiCl）和盐水对照的盐溶液产生味觉厌恶。在单独的实验中，雄性和雌性HDID-1、HDID-2和HS小鼠使用酒精来调节位置偏好。与HS小鼠相比，HDID小鼠对中等剂量（2 g/kg）酒精的敏感性减弱，但对高剂量（4 g/kg）或LiCl或生理盐水注射的条件性味觉厌恶没有差异。HDID和HS小鼠表现出酒精诱导的条件位置偏好的相似发展。这些结果表明，HDID小鼠饮酒后的高血液酒精水平与对酒精的厌恶减弱有关，而这些小鼠对酒精奖励的敏感性没有改变。因此，HDID小鼠可能会发现中等剂量的酒精比对照小鼠更不反感，因此可能会喝得更多，因为这种厌恶敏感性降低了。
Both rewarding and aversive effects contribute to alcohol consumption. Animals genetically predisposed to be high drinkers show reduced sensitivity to the aversive effects of alcohol, and in some instances, increased sensitivity to alcohol’s rewarding effects. The present studies tested the High Drinking in the Dark (HDID) selected lines, a genetic model of drinking to intoxication, to determine whether intake in these mice was genetically related to sensitivity to alcohol aversion or reward. Male HDID mice from the first and second replicate lines (HDID-1 and HDID-2, respectively) and mice from the heterogeneous progenitor control population (HS/Npt, or HS) were conditioned for a taste aversion to a salt solution using 2 doses of alcohol, and lithium chloride (LiCl) and saline controls. In separate experiments, male and female HDID-1, HDID-2, and HS mice were conditioned for place preference using alcohol. HDID mice were found to have an attenuated sensitivity to alcohol at a moderate (2 g/kg) dose compared to HS mice, but did not differ on conditioned taste aversion to a high (4 g/kg) dose or LiCl or saline injections. HDID and HS mice showed comparable development of alcohol-induced conditioned place preference. These results indicate that high blood alcohol levels after drinking in the HDID mice is genetically related to attenuated aversion to alcohol, while sensitivity to alcohol reward is not altered in these mice. Thus, HDID mice may find a moderate dose of alcohol to be less aversive than control mice and consequently may drink more because of this reduced aversive sensitivity.
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影响因子：
3.4
作者：
Matson LM;Grahame NJ
通讯作者：
Grahame NJ
DOI：
10.1111/j.1530-0277.2012.01749.x
发表时间：
2012-08-01
影响因子：
3.2
作者：
Barkley-Levenson, Amanda M.;Crabbe, John C.
通讯作者：
Crabbe, John C.
影响因子：
3.4
作者：
CUNNINGHAM, CL;NIEHUS, DR;PRATHER, LK
通讯作者：
PRATHER, LK
影响因子：
3.4
作者：
Gauvin, DV;Baird, TJ;Briscoe, RJ
通讯作者：
Briscoe, RJ
DOI：
10.1111/j.1530-0277.1993.tb00739.x
发表时间：
1993-02-01
影响因子：
3.2
作者：
MARTIN, CS;EARLEYWINE, M;SWIFT, RM
通讯作者：
SWIFT, RM