Relative contributions of lean and fat mass to bone strength in young Hispanic and non-Hispanic girls.
Relative contributions of lean and fat mass to bone strength in young Hispanic and non-Hispanic girls.
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DOI：
10.1016/j.bone.2018.05.023
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发表时间：
2018-08
期刊：
影响因子：
4.1
通讯作者：
Going SB
中科院分区：
文献类型：
--
作者：
Hetherington-Rauth M;Bea JW;Blew RM;Funk JL;Hingle MD;Lee VR;Roe DJ;Wheeler MD;Lohman TG;Going SB
随着儿童肥胖症的高患病率，特别是在西班牙裔儿童中，了解体重及其瘦体重和脂肪量的组成部分如何影响骨骼发育是很重要的，因为儿童时期积累的骨矿物质量可以决定以后生活中的骨质疏松症风险。本研究的目的是评估西班牙裔和非西班牙裔女孩承重和非承重骨骼中瘦体重和脂肪质量对体积骨密度（vBMD）、几何形状和强度的独立贡献。使用外周定量计算机断层扫描（pQCT）对326名9- 12岁女孩的20%股骨远端、4%和66%胫骨远端以及66%非优势肢体远端桡骨进行骨vBMD、几何结构和强度评估。通过双能X线吸收法（DXA）测量全身瘦体重和脂肪质量。使用多元线性回归评估脂肪和瘦体重与pQCT骨测量的独立关系，同时调整相关混杂因素。还测试了种族与脂肪和瘦体重之间的潜在相互作用。除骨干部位的vBMD外，瘦体重对所有骨结局都有显著的正贡献（p<0.05）。脂肪量是承重部位骨强度的重要贡献者，但对非承重桡骨的骨强度无显著贡献，且与桡骨皮质含量和厚度呈负相关。西班牙裔和非西班牙裔女孩之间的骨测量没有显著差异，尽管种族和脂肪量与股骨（p=0.02）和66%胫骨（p=0.005）的总骨面积以及股骨（p=0.03）的骨强度之间存在显著相互作用。瘦体重是无骨关节部位骨强度的主要决定因素。脂肪量有助于承重骨骼中的骨强度，但不会增加非承重部位的骨强度，并且可能是有害的。西班牙裔和非西班牙裔女孩之间的骨vBMD、几何形状和强度没有差异;与非西班牙裔女孩相比，西班牙裔女孩的负重骨中脂肪量可能是骨强度的更大贡献者。
With the high prevalence of childhood obesity, especially among Hispanic children, understanding how body weight and its components of lean and fat mass affect bone development is important, given that the amount of bone mineral accrued during childhood can determine osteoporosis risk later in life. The aim of this study was to assess the independent contributions of lean and fat mass on volumetric bone mineral density (vBMD), geometry, and strength in both weight-bearing and non-weight-bearing bones of Hispanic and non-Hispanic girls. Bone vBMD, geometry, and strength were assessed at the 20% distal femur, the 4% and 66% distal tibia, and the 66% distal radius of the non-dominant limb of 326, 9- to 12-year-old girls using peripheral quantitative computed tomography (pQCT). Total body lean and fat mass were measured by dual-energy x-ray absorptiometry (DXA). Multiple linear regression was used to assess the independent relationships of fat and lean mass with pQCT bone measures while adjusting for relevant confounders. Potential interactions between ethnicity and both fat and lean mass were also tested. Lean mass was a significant positive contributor to all bone outcomes (p<0.05) with the exception of vBMD at diaphyseal sites. Fat mass was a significant contributor to bone strength at weight bearing sites, but did not significantly contribute to bone strength at the non-weight bearing radius and was negatively associated with radius cortical content and thickness. Bone measures did not significantly differ between Hispanic and non-Hispanic girls, although there was a significant interaction between ethnicity and fat mass with total bone area at the femur (p=0.02) and 66% tibia (p=0.005) as well as bone strength at the femur (p=0.03). Lean mass is the main determinant of bone strength for appendicular skeletal sites. Fat mass contributes to bone strength in the weight-bearing skeleton but does not add to bone strength in non-weight-bearing locations and may potentially be detrimental. Bone vBMD, geometry, and strength did not differ between Hispanic and non-Hispanic girls; fat mass may be a stronger contributor to bone strength in weight-bearing bones of Hispanic girls compared to non-Hispanic.
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影响因子：
4.2
作者：
Alderete, Tanya L.;Toledo-Corral, Claudia M.;Goran, Michael I.
通讯作者：
Goran, Michael I.
影响因子：
4.2
作者：
Farr, Joshua N.;Dimitri, Paul
通讯作者：
Dimitri, Paul
影响因子：
3.4
作者：
Evenson, Kelly R.;Catellier, Diane J.;McMurray, Robert G.
通讯作者：
McMurray, Robert G.
影响因子：
8
作者：
Barlow, Sarah E.
通讯作者：
Barlow, Sarah E.
脂肪组织刺激青春期前儿童的骨骼生长。
DOI：
10.1210/jc.2006-0332
发表时间：
2006-07
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Clark EM;Ness AR;Tobias JH
通讯作者：
Tobias JH