Metabolic basis of ethnic differences in diabetes risk in overweight and obese youth.
Metabolic basis of ethnic differences in diabetes risk in overweight and obese youth.
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DOI：
10.1007/s11892-013-0455-z
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发表时间：
2014-02
影响因子：
4.2
通讯作者：
Goran, Michael I.
中科院分区：
文献类型：
--
作者：
Alderete, Tanya L.;Toledo-Corral, Claudia M.;Goran, Michael I.
关键词：
ObesityYouthInsulin sensitivityAcute insulin responseDisposition indexInsulin secretionbeta-cell functionPrediabetesHemoglobin AlcImpaired glucose toleranceType 2 diabetesmellitusMinoritiesEthnicityEctopic fatSubcutaneous abdominal adipose tissueVisceral adipose tissueIntramyocellular lipidLiver fatNonalcoholic fatty liver diseasePancreatic fatAdipose tissue inflammationdipose tissue fibrosisNonesterified free fatty acids
全球儿童肥胖症的流行导致糖尿病前期和 2 型糖尿病 (T2DM) 的风险增加。研究表明，随着肥胖的增加，胰岛素敏感性和/或分泌会降低，并且一直观察到肥胖的非白人青年患 T2DM 的风险更大。在当前的综述中，我们描述了在了解儿童和青少年的肥胖和代谢状态如何影响拉丁裔、非裔美国人、白种人、亚洲人和美洲原住民中 T2DM 的各种风险状况方面的最新进展。这些可能的决定因素包括异位脂肪分布、脂肪组织炎症和纤维化以及非酯化游离脂肪酸血浆水平升高。未来的工作应旨在阐明 T2DM 的种族特异性病理生理学，以便根据不同种族的糖尿病风险情况制定和实施适当的预防和治疗策略。
The global pandemic of childhood obesity has led to increased risk for prediabetes and type 2 diabetes mellitus (T2DM). Studies have shown decreased insulin sensitivity and/or secretion with increasing adiposity and consistently observed greater risk for T2DM in obese, non-Caucasian youth. In the current review we describe recent advances in understanding how obesity and metabolic status in children and adolescents confers various risk profiles for T2DM among Latinos, African-Americans, Caucasians, Asians and Native Americans. These possible determinants include ectopic fat distribution, adipose tissue inflammation and fibrosis, and elevated plasma levels of non-esterified free fatty acids. Future work should aim to elucidate the ethnic-specific pathophysiology of T2DM in order to develop and implement appropriate prevention and treatment strategies based on different ethnic profiles of diabetes risk.
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影响因子：
16.2
作者：
Cowie CC;Rust KF;Ford ES;Eberhardt MS;Byrd-Holt DD;Li C;Williams DE;Gregg EW;Bainbridge KE;Saydah SH;Geiss LS
通讯作者：
Geiss LS
影响因子：
7.1
作者：
BROUSSARD, BA;JOHNSON, A;GOHDES, D
通讯作者：
GOHDES, D
影响因子：
3.4
作者：
Amed, Shazhan;Hamilton, Jill K.;Dean, Heather
通讯作者：
Dean, Heather
影响因子：
7.7
作者：
Giannini C;Weiss R;Cali A;Bonadonna R;Santoro N;Pierpont B;Shaw M;Caprio S
通讯作者：
Caprio S
影响因子：
5.9
作者：
Gaggini M;Morelli M;Buzzigoli E;DeFronzo RA;Bugianesi E;Gastaldelli A
通讯作者：
Gastaldelli A