Computational Model Exploring Characteristic Pattern Regulation in Periventricular Vessels.
Computational Model Exploring Characteristic Pattern Regulation in Periventricular Vessels.
复制标题
DOI：
10.3390/life12122069
复制
发表时间：
2022-12-09
期刊：
影响因子：
3.2
通讯作者：
Mizutani, Ken-ichi
中科院分区：
文献类型：
--
作者：
Takigawa-Imamura, Hisako;Hirano, Saito;Watanabe, Chisato;Ohtaka-Maruyama, Chiaki;Ema, Masatsugu;Mizutani, Ken-ichi
发育中的新皮质血管系统在每一层中都表现出独特的模式。在小鼠胚胎中，皮质板（CP）中的血管是垂直定向的，而中间区（IZ）和脑室下区（SVZ）中的血管形成蜂窝状结构。组织特异性血管的形成表明内皮细胞的行为在每层中处于特定的调节机制下，尽管所涉及的机制仍然未知。在本研究中，我们的目的是探索所需的条件，通过使用计算模型进行模拟，形成这些血管图案。我们开发了一种新的模型框架，描述了集体迁移的内皮细胞代表血管生成的过程，并进行了模拟使用二维近似。基于VEGF和Unc配体等导向分子的功能和分布，将尖端细胞的吸引和排斥导向纳入模型。结果表明，一个适当的组合的指导效果再现的平行直模式在CP和网状图案在IZ/SVZ。我们的模型展示了尖端细胞的指导如何导致各种血管模式，并预测了组织特异性血管形成如何在新皮层血管的早期发育中受到调节。
The developing neocortical vasculature exhibits a distinctive pattern in each layer. In murine embryos, vessels in the cortical plate (CP) are vertically oriented, whereas those in the intermediate zone (IZ) and the subventricular zone (SVZ) form a honeycomb structure. The formation of tissue-specific vessels suggests that the behavior of endothelial cells is under a specific regulatory regime in each layer, although the mechanisms involved remain unknown. In the present study, we aimed to explore the conditions required to form these vessel patterns by conducting simulations using a computational model. We developed a novel model framework describing the collective migration of endothelial cells to represent the angiogenic process and performed a simulation using two-dimensional approximation. The attractive and repulsive guidance of tip cells was incorporated into the model based on the function and distribution of guidance molecules such as VEGF and Unc ligands. It is shown that an appropriate combination of guidance effects reproduces both the parallel straight pattern in the CP and meshwork patterns in the IZ/SVZ. Our model demonstrated how the guidance of the tip cell causes a variety of vessel patterns and predicted how tissue-specific vascular formation was regulated in the early development of neocortical vessels.
登录
查看更多内容
DOI：
10.1038/nrm3176
发表时间：
2011-08-23
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.4
作者：
Blanco, Raquel;Gerhardt, Holger
通讯作者：
Gerhardt, Holger
影响因子：
4.6
作者：
Nesmith, Jessica E.;Chappell, John C.;Bautch, Victoria L.
通讯作者：
Bautch, Victoria L.
影响因子：
1.7
作者：
Merks, RMH;Glazier, JA
通讯作者：
Glazier, JA
影响因子：
1.6
作者：
Claro V;Ferro A
通讯作者：
Ferro A