Characterization of the oxysterol-binding protein gene family in the yellow fever mosquito, Aedes aegypti.
Characterization of the oxysterol-binding protein gene family in the yellow fever mosquito, Aedes aegypti.
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DOI：
10.1111/j.1365-2583.2011.01087.x
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发表时间：
2011-08
影响因子：
2.6
通讯作者：
Lan Q
中科院分区：
文献类型：
--
作者：
Fu Q;Lynn-Miller A;Lan Q
氧化甾醇结合蛋白(OSBP)和相关蛋白(ORPs)是一类可能参与细胞内固醇转运、代谢和信号转导的固醇结合蛋白。从埃及伊蚊中克隆了4个ORP基因。根据与人类蛋白质的氨基酸序列同源性，它们是AeOSBP、AeORP1、AeORP8和AeORP9。确定了AeOSBP和AeORP8的剪接变异体。分析了AeOSBP基因家族成员在发育阶段和生殖营养周期中的时空转录模式。AeORP1的转录似乎是头部组织特异性的，而AeOSBP和AeORP9的表达是由血餐诱导的。此外，AeORPs的过表达促进了埃及伊蚊培养的Aag-2细胞摄取[~3H]-胆固醇。
The oxysterol-binding protein (OSBP) and related proteins (ORPs) are sterol-binding proteins that may be involved in cellular sterol transportation, sterol metabolism and signal transduction pathways. Four ORP genes were cloned from Aedes aegypti. Based on amino acid sequence homology to human proteins, they are AeOSBP, AeORP1, AeORP8 and AeORP9. Splicing variants of AeOSBP and AeORP8 were identified. The temporal and spatial transcription patterns of members of the AeOSBP gene family through developmental stages and the gonotrophic cycle were profiled. AeORP1 transcription seemed to be head tissue-specific, whereas AeOSBP and AeORP9 expressions were induced by a blood meal. Furthermore, over-expression of AeORPs facilitated [3H]-cholesterol uptake in Aedes aegypti cultured Aag-2 cells.
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影响因子：
2.6
作者：
Krebs, KC;Lan, Q
通讯作者：
Lan, Q
影响因子：
4.8
作者：
Furuita, Kyoko;Jee, JunGoo;Kojima, Chojiro
通讯作者：
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OSBP 和 FAN 介导的果蝇精子发生的甾醇需求
影响因子：
4.6
作者：
Ma, Zhiguo;Liu, Zhonghua;Huang, Xun
通讯作者：
Huang, Xun
影响因子：
2.1
作者：
Ibrahim, MS;Eisinger, SW;Scott, AL
通讯作者：
Scott, AL
影响因子：
4.1
作者：
Gilbert, LI
通讯作者：
Gilbert, LI