Parental sensitivity mediates the sustained effect of Attachment and Biobehavioral Catch-up on cortisol in middle childhood: A randomized clinical trial.
Parental sensitivity mediates the sustained effect of Attachment and Biobehavioral Catch-up on cortisol in middle childhood: A randomized clinical trial.
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DOI：
10.1016/j.psyneuen.2020.104809
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发表时间：
2020-11
影响因子：
3.7
通讯作者：
Dozier M
中科院分区：
文献类型：
--
作者：
Garnett M;Bernard K;Hoye J;Zajac L;Dozier M
父母的干预措施已被发现正常儿童的皮质醇调节中的高风险儿童在发展的早期，重要的是要调查这些影响的可持续性及其机制，考虑到适应不良的结果与皮质醇失调。确定是否依恋和生物行为追赶（ABC）干预，在婴儿期实施，预测皮质醇调节在童年中期通过父母的敏感性变化。双盲随机临床试验设计; 2006年1月开始，该项目的后续行动于2016年3月结束，在大西洋中部的一个大城市，2岁以下儿童的父母从儿童保护服务机构转介了103个亲子配对（45.6%的女童）有儿童保护服务参与的历史，随机分配接受ABC（n = 45）或对照干预（n = 58）;在婴儿期，儿童的年龄范围为1.60至25.30个月（M = 9.87个月）;在儿童中期随访时，他们的年龄范围为8.0至11.0岁（M = 8.52岁）。这两种情况都包括10周的家庭手动干预。实验条件，ABC，有3个主要目标的父母：增加养育孩子的痛苦，增加以下儿童的领导，并减少可怕的行为。控制干预，发展教育的家庭（DEF），是一个适应计划，重点是提高认知和语言发展。父母的敏感性编码从一个半结构化的互动任务之间的父母和儿童在幼儿期。通过连续3天收集儿童起床和就寝时的唾液皮质醇样本，对儿童中期昼夜皮质醇斜率进行建模。婴儿期ABC参与与干预后父母敏感性的增加相关，β = 0.28，p = 0.004，这种敏感性的增加预测了儿童中期皮质醇浓度的急剧下降，β =-0.53，p = 0.002。ABC通过敏感性对皮质醇调节的间接影响是显著的，β =-0.15，p = 0.038。ABC通过父母的敏感性对儿童中期的昼夜皮质醇调节产生间接影响;未来的研究应寻求确定这种增强的神经生物学调节与儿童的行为，社会情感和心理结果的关系。clinicaltrials.gov NCT02093052面临早期生活逆境的儿童通常表现出下丘脑垂体肾上腺（HPA）轴功能失调，表现为皮质醇昼夜节律迟钝。依恋和生物行为追赶（ABC）是一种干预措施，旨在通过针对父母的敏感性来加强早期逆境儿童的生物和行为调节。在婴儿期实施，ABC已被发现对儿童的昼夜皮质醇产生持续影响到幼儿期。本研究探讨了ABC对儿童中期皮质醇调节的持久影响，并研究了父母敏感性作为中介的作用。参与者是103名儿童保护服务转介的儿童和他们的父母谁参加了ABC的随机临床试验。在干预后（M年龄= 20.66 [5.23]个月），父母的敏感性编码从半结构化的互动任务。在儿童中期，父母连续3天在起床和就寝时从他们的孩子（M年龄= 8.52 [0.67]岁）收集唾液样本。分析样品以确定皮质醇浓度，并将昼夜皮质醇斜率估计为潜在变化评分。随机分配到ABC组的父母在孩子婴儿期的父母敏感性比对照组的父母高，β = 0.28，p = 0.004，这种敏感性的增加预示着在儿童中期从醒来到就寝时皮质醇浓度的下降更陡峭，更规范，β =-0.53，p = 0.002。此外，ABC通过干预后敏感性对儿童昼夜皮质醇斜率的间接影响是显著的，β =-0.15，p = 0.038，表明父母的敏感性介导了ABC与儿童中期昼夜皮质醇斜率之间的关联。
Parenting interventions have been found to normalize children’s cortisol regulation among high-risk children early in development; it is important to investigate sustainability of these effects and their mechanisms, given the maladaptive outcomes associated with cortisol dysregulation. To determine whether the Attachment and Biobehavioral Catch-up (ABC) intervention, implemented in infancy, predicts cortisol regulation in middle childhood via changes in parental sensitivity. Double blind randomized clinical trial design; started January 2006, with the follow-up for this project concluded March 2016 Parents of children under age 2 referred from child protective services agencies in a large, mid-Atlantic city 103 parent-child dyads (45.6% female children) with histories of child protective services involvement, randomly assigned to receive ABC (n = 45) or a control intervention (n = 58); in infancy, the children’s ages ranged from 1.60 to 25.30 months (M = 9.87 months); at the middle childhood follow-up, they ranged from 8.0 to 11.0 years old (M = 8.52 years). Both conditions included 10-week, in-home, manualized interventions. The experimental condition, ABC, has 3 primary targets for parents: increasing nurturance to child distress, increasing following the child’s lead, and decreasing frightening behavior. The control intervention, Developmental Education for Families (DEF), is an adaptation of a program focused on enhancing cognitive and language development. Parental sensitivity was coded from a semi-structured interaction task between the parent and child in early childhood. Middle childhood diurnal cortisol slopes were modeled by collecting salivary cortisol samples from children at wake-up and bedtime over the course of 3 consecutive days. ABC participation in infancy was associated with increased parental sensitivity post-intervention, β = 0.28, p = .004, and this increased sensitivity predicted steeper decline across the day in children’s cortisol concentration in middle childhood, β = −.53, p= .002. The indirect effect of ABC on cortisol regulation via sensitivity was significant, β = −0.15, p = .038. ABC has an indirect effect on middle childhood diurnal cortisol regulation via parental sensitivity; future research should seek to determine how this enhanced neurobiological regulation relates to children’s behavioral, socioemotional, and psychological outcomes. clinicaltrials.gov Identifier: NCT02093052 Children facing early life adversity often show dysregulated functioning of the hypothalamic pituitary adrenal (HPA) axis in the form of blunted diurnal cortisol rhythms. Attachment and Biobehavioral Catch-up (ABC) is an intervention developed to enhance biological and behavioral regulation in children exposed to early adversity by targeting parental sensitivity. Implemented in infancy, ABC has been found to have lasting effects on children’s diurnal cortisol production into early childhood. The present study explored the enduring impact of ABC on cortisol regulation in middle childhood and examined the role of parental sensitivity as a mediator. Participants were 103 Child Protective Services referred children and their parents who participated in a randomized clinical trial of ABC. At post-intervention (M age = 20.66 [5.23] months), parental sensitivity was coded from a semi-structured interaction task. In middle childhood, parents collected saliva samples from their child (M age = 8.52 [0.67] years) at wake-up and bedtime for 3 consecutive days. Samples were assayed to determine cortisol concentration and the diurnal cortisol slope was estimated as a latent change score. Parents who were randomized to ABC were rated higher in parental sensitivity during their children’s infancy than parents in the control group, β = 0.28, p = .004, and this increased sensitivity predicted a steeper, more normative decline in cortisol concentration from wake-up to bedtime in middle childhood, β = −.53, p = .002. Further, the indirect effect of ABC on children’s diurnal cortisol slope via post-intervention sensitivity was significant, β = −0.15, p = .038, suggesting that parental sensitivity mediated the association between ABC and children’s diurnal cortisol slope in middle childhood.
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影响因子：
4.6
作者：
Bernard K;Dozier M;Bick J;Lewis-Morrarty E;Lindhiem O;Carlson E
通讯作者：
Carlson E
DOI：
10.1001/archpediatrics.2010.54
发表时间：
2010-05-01
影响因子：
--
作者：
Bernard, Kristin;Butzin-Dozier, Zachary;Dozier, Mary
通讯作者：
Dozier, Mary
影响因子：
4.6
作者：
Bernard K;Simons R;Dozier M
通讯作者：
Dozier M
DOI：
10.1080/10705510701301834
发表时间：
2005-01-01
影响因子：
6
作者：
Chen, FF;Sousa, KH;West, SG
通讯作者：
West, SG
昼夜皮质醇斜率以及心理和身体健康结果：系统评价和荟萃分析。
影响因子：
3.7
作者：
Adam EK;Quinn ME;Tavernier R;McQuillan MT;Dahlke KA;Gilbert KE
通讯作者：
Gilbert KE