The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation.
The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation.
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DOI：
10.1016/j.cell.2020.10.024
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发表时间：
2020-11-25
期刊：
影响因子：
64.5
通讯作者：
Behrens TEJ
中科院分区：
文献类型：
--
作者：
Whittington JCR;Muller TH;Mark S;Chen G;Barry C;Burgess N;Behrens TEJ
海马体-内嗅觉系统对于空间和关系记忆任务非常重要。我们正式地将这些领域联系在一起，提供了对海马体在泛化中的作用的机械理解，并提供了许多内嗅觉和海马体细胞类型的统一原则。我们认为内侧内嗅觉细胞形成了描述结构知识的基础，而海马体细胞将这一基础与感觉表征联系起来。采用这些原理，我们介绍了Tolman-Eichenbaum机器。学习后，透射电子显微镜内嗅细胞表现出明显定制的空间反应的不同属性，如网格、带、边界和目标载体细胞。TEM海马区细胞包括在不同环境之间重新映射的位置细胞和标志性细胞。重要的是，在复杂的非空间任务中，瞬变记忆也与经验记录的表征相一致。TEM还产生预测，即海马区的重新映射并不像以前认为的那样是随机的；相反，结构知识在不同的环境中被保留。我们在同时记录的位置和网格单元中证实了这种结构转移和重新映射。海马体结构中空间和关系记忆的共同原理解释了海马体在空间和非空间问题中的概化解释了许多已报道的海马体和内嗅觉细胞类型从这类任务中预测海马体如何在空间和非空间任务中重新映射Tolman-Eichenbaum机器，以纪念Edward Chace Tolman和Howard Eichenbaum对认知理论的贡献，为海马体在空间和非空间泛化中的作用提供了一个统一的框架，并统一了许多内嗅器和海马体细胞类型背后的统一原理。
The hippocampal-entorhinal system is important for spatial and relational memory tasks. We formally link these domains, provide a mechanistic understanding of the hippocampal role in generalization, and offer unifying principles underlying many entorhinal and hippocampal cell types. We propose medial entorhinal cells form a basis describing structural knowledge, and hippocampal cells link this basis with sensory representations. Adopting these principles, we introduce the Tolman-Eichenbaum machine (TEM). After learning, TEM entorhinal cells display diverse properties resembling apparently bespoke spatial responses, such as grid, band, border, and object-vector cells. TEM hippocampal cells include place and landmark cells that remap between environments. Crucially, TEM also aligns with empirically recorded representations in complex non-spatial tasks. TEM also generates predictions that hippocampal remapping is not random as previously believed; rather, structural knowledge is preserved across environments. We confirm this structural transfer over remapping in simultaneously recorded place and grid cells. Common principles for space and relational memory in the hippocampal formation Explains hippocampal generalization in both spatial and non-spatial problems Accounts for many reported hippocampal and entorhinal cell types from such tasks Predicts how hippocampus remaps in both spatial and non-spatial tasks The Tolman-Eichenbaum Machine, named in honor of Edward Chace Tolman and Howard Eichenbaum for their contributions to cognitive theory, provides a unifying framework for the hippocampal role in spatial and nonspatial generalization and unifying principles underlying many entorhinal and hippocampal cell types.
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我们能否调和关于海马功能的陈述性记忆和空间导航观点？
影响因子：
16.2
作者：
Eichenbaum H;Cohen NJ
通讯作者：
Cohen NJ
DOI：
10.1073/pnas.94.13.7109
发表时间：
1997-06-24
影响因子：
11.1
作者：
Dusek, JA;Eichenbaum, H
通讯作者：
Eichenbaum, H
影响因子：
25
作者：
Derdikman, Dori;Whitlock, Jonathan R.;Moser, Edvard I.
通讯作者：
Moser, Edvard I.
使用非阴性主成分分析从位置细胞输入中提取网格细胞特征。
影响因子：
7.7
作者：
Dordek Y;Soudry D;Meir R;Derdikman D
通讯作者：
Derdikman D
影响因子：
64.8
作者：
Bunsey, M;Eichenbaum, H
通讯作者：
Eichenbaum, H