Microbial persistence and the road to drug resistance.
Microbial persistence and the road to drug resistance.
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DOI：
10.1016/j.chom.2013.05.009
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发表时间：
2013-06-12
影响因子：
30.3
通讯作者：
Collins JJ
中科院分区：
文献类型：
--
作者：
Cohen NR;Lobritz MA;Collins JJ
微生物药物持久性是一种广泛存在的现象，其中一种微生物亚群能够在抗菌素治疗中存活而不获得赋予耐药性的遗传变化。微生物持续存在可引起复发性或顽固性感染，并且与耐药突变体一样，它们带来越来越大的临床负担。然而，与遗传耐药性相比，持久性的生物学才刚刚开始被解开。传统上，持久性细胞被认为是代谢休眠的、不分裂的细胞。然而，正如本文所讨论的，越来越多的证据表明，持久性实际上是一种积极维持的状态，由细胞内应激反应网络触发和实现，可以加速适应性进化过程。除了揭示持久性的基础之外，这些发现还提出了一种可能性，即持久性充当了一个进化储存库，从中可以出现抗性生物。随着持久性及其后果变得更加清晰，迫切需要临床相关的根除策略。
Microbial drug persistence is a widespread phenomenon in which a sub-population of microorganisms is able to survive antimicrobial treatment without acquiring resistance-conferring genetic changes. Microbial persisters can cause recurrent or intractable infections, and like resistant mutants, they carry an increasing clinical burden. In contrast to heritable drug resistance, however, the biology of persistence is only beginning to be unraveled. Persisters have traditionally been thought of as metabolically dormant, non-dividing cells. However, as discussed in this review, increasing evidence suggests that persistence is in fact an actively maintained state, triggered and enabled by a network of intracellular stress-responses that can accelerate processes of adaptive evolution. Beyond shedding light on the basis of persistence, these findings raise the possibility that persisters behave as an evolutionary reservoir from which resistant organisms can emerge. As persistence and its consequences come into clearer focus, clinically relevant eradication strategies are urgently needed.
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影响因子：
64.8
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1003219107
发表时间：
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作者：
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通讯作者：
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