Heterogeneous bacterial persisters and engineering approaches to eliminate them.

Heterogeneous bacterial persisters and engineering approaches to eliminate them.
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DOI:
10.1016/j.mib.2011.09.002
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发表时间:
2011-10
影响因子:
5.4
通讯作者:
Collins, James J.
Collins, James J.
中科院分区:
生物学2区
文献类型:
--
作者:
Allison, Kyle R.;Brynildsen, Mark P.;Collins, James J.

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细菌持久性是一种细胞亚群(持久性)在抗生素治疗中存活的状态,它与临床感染的耐受性和生物膜的顽固性有关。鉴于最近的大量发现,人们对细菌在治疗失败中的作用重新产生了兴趣。在这里,我们回顾了最近对细菌持久性的实验室研究。此外,我们提出假设,每个细菌群体可能包含不同的持久性集合,并讨论持久性根除的工程策略。
Bacterial persistence is state in which a sub-population of cells (persisters) survives antibiotic treatment, and has been implicated in the tolerance of clinical infections and the recalcitrance of biofilms. There has been a renewed interest in the role of bacterial persisters in treatment failure in light of a wealth of recent findings. Here we review recent laboratory studies of bacterial persistence. Further, we pose the hypothesis that each bacterial population may contain a diverse collection of persisters and discuss engineering strategies for persister eradication.
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