Hippo Signaling Pathway in Pancreas Development.
Hippo Signaling Pathway in Pancreas Development.
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DOI：
10.3389/fcell.2021.663906
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发表时间：
2021
影响因子：
5.5
通讯作者：
Wang P
中科院分区：
文献类型：
--
作者：
Wu Y;Aegerter P;Nipper M;Ramjit L;Liu J;Wang P
Hippo信号通路是胰腺发育和稳态的重要调节因子，指导细胞命运决定、形态发生和成年胰腺细胞可塑性。通过功能丧失研究，发现Hippo信号传导在维持胰腺器官发生中祖细胞更新、增殖和分化之间的适当平衡中发挥关键作用。其他研究表明，雅普（该途径的下游效应物）的过度活化促进导管细胞发育并通过Ngn 3的抑制抑制内分泌细胞命运特化。出生后，已经发现Hippo信号传导的中断导致腺泡细胞的去分化和胰腺炎样表型。此外，Hippo信号传导通过确保适当的细胞极化和分支来指导胰腺形态发生。尽管有这些发现，但Hippo控制细胞分化和胰腺结构的机制尚未完全了解。本文综述了Hippo在胰腺发育中的作用，包括与NOTCH、WNT/β-catenin和PI 3 K/Akt/mTOR信号通路的相互作用。
The Hippo signaling pathway is a vital regulator of pancreatic development and homeostasis, directing cell fate decisions, morphogenesis, and adult pancreatic cellular plasticity. Through loss-of-function research, Hippo signaling has been found to play key roles in maintaining the proper balance between progenitor cell renewal, proliferation, and differentiation in pancreatic organogenesis. Other studies suggest that overactivation of YAP, a downstream effector of the pathway, promotes ductal cell development and suppresses endocrine cell fate specification via repression of Ngn3. After birth, disruptions in Hippo signaling have been found to lead to de-differentiation of acinar cells and pancreatitis-like phenotype. Further, Hippo signaling directs pancreatic morphogenesis by ensuring proper cell polarization and branching. Despite these findings, the mechanisms through which Hippo governs cell differentiation and pancreatic architecture are yet to be fully understood. Here, we review recent studies of Hippo functions in pancreatic development, including its crosstalk with NOTCH, WNT/β-catenin, and PI3K/Akt/mTOR signaling pathways.
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