How Computational Modeling can Help to Predict Gas Transfer in Artificial Lungs Early in the Design Process
How Computational Modeling can Help to Predict Gas Transfer in Artificial Lungs Early in the Design Process
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计算模型如何帮助在设计过程的早期预测人工肺中的气体传输
DOI：
10.1097/mat.0000000000001098
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发表时间：
1992
期刊：
影响因子：
4.2
通讯作者：
Ulrich
中科院分区：
文献类型：
--
作者：
Kaesler;Andreas;Marius;Schlanstein;Peter C;Wagner;Groß-Hardt;Sascha;Schmitz-Rode;Thomas;Steinseifer;Ulrich
可穿戴式体外膜氧合（ECMO）回路可能很快成为传统ECMO治疗的可行替代方案。然而，必须首先解决常见的器械引起的并发症，如血液创伤和氧合器血栓形成，以提高长期可靠性，因为不能像重症监护患者那样密切监测非卧床患者。另外，膜表面的有效使用可以减小装置的尺寸、预充体积和重量以实现便携性。这两个挑战都与纤维束中的血液动力学有关。虽然实验测试方法通常只能提供全局和时间平均信息，但计算流体动力学（CFD）可以在构建第一个实验室原型之前深入了解局部流动动力学和气体传输。在这项研究中，我们应用我们以前介绍的微尺度CFD模型的全纤维束的小型氧合器的气体传输预测。三个随机的几何形状，以及交错和线配置进行建模和模拟与Ansys CFX。三个小型实验室氧合器原型是通过单向堆叠纤维段，在连续段之间使用间隔物构建的。根据ISO 7199，在体外对器械进行了使用猪血的气体转移试验。对于100、200、300和400 ml/min的血液流速，随机1、2和3配置的预测平均CFD氧饱和度相对于平均体外数据（所有样本和器械）的误差分别为2.4%、4.6%、3.1%和3.0%。虽然我们的微尺度CFD模型已成功应用于具有单向纤维的小型氧合器，但由于纤维束中的复杂流量分布和高计算成本，临床相关氧合器的应用仍具有挑战性。然而，我们将概述我们未来的研究重点，并讨论如何扩展的传质相关模型实施到计算流体力学可能使一个先验预测的气体传输在全尺寸氧合器。
Wearable extracorporeal membrane oxygenation (ECMO) circuits may soon become a viable alternative to conventional ECMO treatment. Common device-induced complications, however, such as blood trauma and oxygenator thrombosis, must first be addressed to improve long-term reliability, since ambulatory patients cannot be monitored as closely as intensive care patients. Additionally, an efficient use of the membrane surface can reduce the size of the devices, priming volume, and weight to achieve portability. Both challenges are linked to the hemodynamics in the fiber bundle. While experimental test methods can often only provide global and time-averaged information, computational fluid dynamics (CFD) can give insight into local flow dynamics and gas transfer before building the first laboratory prototype. In this study, we applied our previously introduced micro-scale CFD model to the full fiber bundle of a small oxygenator for gas transfer prediction. Three randomized geometries as well as a staggered and in-line configuration were modeled and simulated with Ansys CFX. Three small laboratory oxygenator prototypes were built by stacking fiber segments unidirectionally with spacers between consecutive segments. The devices were tested in vitro for gas transfer with porcine blood in accordance with ISO 7199. The error of the predicted averaged CFD oxygen saturations of the random 1, 2, and 3 configurations relative to the averaged in-vitro data (over all samples and devices) was 2.4%, 4.6%, 3.1%, and 3.0% for blood flow rates of 100, 200, 300, and 400 ml/min, respectively. While our micro-scale CFD model was successfully applied to a small oxygenator with unidirectional fibers, the application to clinically relevant oxygenators will remain challenging due to the complex flow distribution in the fiber bundle and high computational costs. However, we will outline our future research priorities and discuss how an extended mass transfer correlation model implemented into CFD might enable an a priori prediction of gas transfer in full size oxygenators.
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氧气转移到圆管中流动的血液，包括玻尔效应和霍尔丹效应
DOI：
--
发表时间：
1967
期刊：
影响因子：
--
作者：
J. C. Fair;M. Weissman
通讯作者：
M. Weissman
血液氧合器设计中非牛顿剪切稀化流体的孔隙尺度建模。
DOI：
10.1115/1.4032801
发表时间：
2016
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Kenny W. Q. Low;R. Van Loon;S. Rolland;J. Sienz
通讯作者：
J. Sienz
利用两相欧拉-欧拉模型并包括稳态氧-血红蛋白反应近似分析矩形微通道中的低雷诺数血流
影响因子：
1.4
作者：
Jamie L. Wright
通讯作者：
Jamie L. Wright
集成磁悬浮泵氧合器的计算设计和体外表征。
影响因子：
2.4
作者：
Juntao Zhang;M. Taskin;A. Koert;Zhang Tao;B. Gellman;K. Dasse;R. Gilbert;B. Griffith;Zhongjun J. Wu
通讯作者：
Zhongjun J. Wu
测定中空纤维膜束各向异性渗透率的实验方法
DOI：
--
发表时间：
2018
期刊：
影响因子：
--
作者：
P. Schlanstein;A. Limper;Felix Hesselmann;T. Schmitz;U. Steinseifer;J. Arens
通讯作者：
J. Arens