Lobule type and subsequent breast cancer risk: results from the Nurses' Health Studies.
Lobule type and subsequent breast cancer risk: results from the Nurses' Health Studies.
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DOI：
10.1002/cncr.24167
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发表时间：
2009-04-01
期刊：
影响因子：
6.2
通讯作者：
Tamimi RM
中科院分区：
文献类型：
--
作者：
Baer HJ;Collins LC;Connolly JL;Colditz GA;Schnitt SJ;Tamimi RM
正常乳腺组织中的小叶可以根据其发育程度进行分类，这可能会影响其对癌变的易感性;然而，很少有流行病学研究对此进行了讨论。我们在护士健康研究（200例病例，915例对照）中对良性乳腺疾病（BBD）和乳腺癌进行了巢式病例对照研究，研究小叶类型与随后的乳腺癌风险之间的关系。良性乳腺活检载玻片由病理学家进行审查，正常终末导管小叶单位分为无1型小叶、混合小叶类型或主要1型小叶和无3型小叶。Logistic回归用于计算小叶类型与乳腺癌风险之间关系的比值比（OR）和95%置信区间（CI）。主要为1型小叶且无3型小叶的女性（54例，321例对照）与无1型小叶或混合型小叶的患者相比，患乳腺癌的风险降低（OR = 0.63，95%CI = 0.44-0.91），尽管在调整BBD的组织学分类后（OR = 0.71，95%CI = 0.49-1.02），这种影响减弱。对于所有类型的BBD，具有主要的1型小叶而没有3型小叶与相似的风险降低相关（非增殖性：OR = 0.73，95% CI：0.36-1.50;增殖性无肥大：OR = 0.80，95% CI = 0.47-1.35;非典型增生：OR = 0.61，95% CI：0.28-1.35）。这些结果提供了初步证据，表明小叶类型可能是BBD女性乳腺癌风险的重要标志物。
Lobules in normal breast tissue can be classified based on their degree of development, which may affect their susceptibility to carcinogenesis; few epidemiologic studies, however, have addressed this. We examined the association between lobule type and subsequent breast cancer risk in a nested case-control study of benign breast disease (BBD) and breast cancer within the Nurses’ Health Studies (200 cases, 915 controls). Benign breast biopsy slides were reviewed by pathologists, and normal terminal duct lobular units were classified as having no type 1 lobules, mixed lobule types, or predominant type 1 and no type 3 lobules. Logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) for the association between lobule type and breast cancer risk. Women with predominant type 1 and no type 3 lobules (54 cases, 321 controls) had a decreased risk of breast cancer compared to those with no type 1 lobules or mixed lobule types (OR = 0.63, 95% CI = 0.44–0.91), although this was attenuated after adjustment for histologic category of BBD (OR = 0.71, 95% CI = 0.49–1.02). Having predominant type 1 lobules and no type 3 lobules was associated with a similar risk reduction for all categories of BBD (nonproliferative: OR = 0.73, 95% CI: 0.36–1.50; proliferative without atypia: OR = 0.80, 95% CI = 0.47–1.35; atypical hyperplasia: OR = 0.61, 95% CI: 0.28–1.35). These results provide preliminary evidence that lobule type may be an important marker of breast cancer risk in women with BBD.
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影响因子：
6.2
作者：
HENSON, DE;TARONE, RE
通讯作者：
TARONE, RE
影响因子：
120.7
作者：
LONDON, SJ;CONNOLLY, JL;COLDITZ, GA
通讯作者：
COLDITZ, GA
影响因子：
5
作者：
COLDITZ, GA;STAMPFER, MJ;SPEIZER, FE
通讯作者：
SPEIZER, FE
影响因子：
3.8
作者：
Russo, J;Tay, L K;Russo, I H
通讯作者：
Russo, I H
影响因子：
6.2
作者：
HENSON, DE;TARONE, RE
通讯作者：
TARONE, RE