Deficient responses from the lateral geniculate nucleus in humans with amblyopia.
Deficient responses from the lateral geniculate nucleus in humans with amblyopia.
复制标题
弱视人类中侧向基因核的反应不足。
DOI：
10.1111/j.1460-9568.2009.06650.x
复制
发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Mullen KT
中科院分区：
文献类型：
--
作者：
Hess RF;Thompson B;Gole G;Mullen KT
弱视或弱视是成年人单眼失明的最常见原因。它是由正常视觉发育中断引起的，这是由于在生命早期两只眼睛的不匹配输入造成的，这是由转动眼睛（斜视）、不等屈光不正（屈光参差）或形觉剥夺（例如白内障）引起的。基于麻醉动物细胞外记录的动物模型表明，灵长类视觉通路异常的最早部位是初级视皮层（对应于纹状皮质，细胞结构区17和区域V1），这是来自两只眼睛的输入首先以兴奋方式组合的地方，而更远的单眼处理结构如视网膜和外侧膝状体核（LGN）是正常的。使用高场功能性磁共振成像在一组成人弱视，我们证明，功能缺陷是第一次观察到在丘脑水平，即LGN。我们的研究结果表明，需要重新评估目前的弱视模型，是基于一个纯粹的皮质功能障碍的假设，以及在视觉发育中的作用，为LGN。
Amblyopia or lazy eye is the most common cause of uniocular blindness in adults. It is caused by a disruption to normal visual development as a consequence of unmatched inputs from the two eyes in early life, arising from a turned eye (strabismus), unequal refractive error (anisometropia) or form deprivation (e.g. cataract). Animal models based on extracellular recordings in anesthetized animals suggest that the earliest site of the anomaly in the primate visual pathway is the primary visual cortex (corresponding to the striate cortex, cytoarchitectonic area 17 and area V1), which is where inputs from the two eyes are first combined in an excitatory fashion, whereas more distal and monocular processing structures such as the retina and lateral geniculate nucleus (LGN) are normal. Using high-field functional magnetic resonance imaging in a group of human adults with amblyopia, we demonstrate that functional deficits are first observable at a thalamic level, that of the LGN. Our results suggest the need to re-evaluate the current models of amblyopia that are based on the assumption of a purely cortical dysfunction, as well as the role for the LGN in visual development.
登录
查看更多内容
影响因子：
2.5
作者：
Kastner, S;O'Connor, DH;Pinsk, MA
通讯作者：
Pinsk, MA
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
0.9
作者：
Bozkurt, Banu;Irkec, Murat;Karaagaoglu, Ergun
通讯作者：
Karaagaoglu, Ergun
影响因子：
1.8
作者：
HESS, RF;BAKER, CL
通讯作者：
BAKER, CL
DOI：
10.1073/pnas.91.15.6938
发表时间：
1994-07-19
影响因子：
11.1
作者：
CHINO, YM;CHENG, H;SUR, M
通讯作者：
SUR, M