Enhanced vulnerability to the rewarding effects of nicotine during the adolescent period of development.
Enhanced vulnerability to the rewarding effects of nicotine during the adolescent period of development.
复制标题
增强了对青少年发展时期尼古丁奖励影响的脆弱性。
DOI：
10.1016/j.pbb.2008.05.009
复制
发表时间：
2008-10
影响因子：
3.6
通讯作者：
O'Dell, Laura E.
中科院分区：
文献类型：
--
作者：
Torres, Oscar V.;Tejeda, Hugo A.;Natividad, Luis A.;O'Dell, Laura E.
关键词：
这项研究比较了在青春期预先接触尼古丁的青春期、成年和成年大鼠尼古丁的奖赏和厌恶效应。在条件反射之前，测试大鼠对两个不同隔室中的任何一个的初始偏好。然后，青少年和成年大鼠在最初的非偏好一侧接受不同剂量的尼古丁，每隔一天在另一侧接受生理盐水。这一为期2天的程序连续8天重复。在条件反射之后，对老鼠的偏好进行了重新测试。另一组青春期和成年组的大鼠被给予不同剂量的d-苯丙胺。尼古丁在两个年龄组均以倒U形方式产生CPP。然而，青少年的CPP表现出更大的上升趋势，这在相对于成年人的更大剂量范围内是显著的。D-苯丙胺所产生的CPP无发育差异。在最后一项研究中，青少年被准备用泵输送尼古丁14天。这些大鼠在成年后使用之前使用的相同程序进行条件训练。在青春期预先接触尼古丁可以减少幼稚成年人服用最高剂量尼古丁所产生的不良反应。综上所述，这些研究为青春期尼古丁易感性的增强提供了基础。
This study compared the rewarding and aversive effects of nicotine in adolescent, adult, and adult rats pre-exposed to nicotine during adolescence. Prior to conditioning, the rats were tested for their initial preference for either of 2 distinct compartments. Adolescent and adult rats then received various nicotine doses in their initially non-preferred side on one day and saline in the other side on alternate days. This 2-day procedure was repeated over 8 consecutive days. Following conditioning, rats were re-tested for their preference. Another cohort of adolescent and adult rats were conditioned with various doses of d-amphetamine. Nicotine produced CPP in an inverted U-shaped manner in both age groups. However, adolescents displayed a larger upward shift in CPP that was significant across a wider dose range relative to adults. There were no developmental differences to CPP produced by d-amphetamine. In a final study, adolescents were prepared with pumps that delivered nicotine for 14 days. These rats were conditioned later as adults using the same procedures used previously. Pre-exposure to nicotine during adolescence diminished the aversive effects produced by the highest nicotine dose in naïve adults. Taken together, these studies provide a basis for enhanced vulnerability to nicotine during adolescence.
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影响因子：
3.6
作者：
Faraday, MM;Elliott, BM;Grunberg, NE
通讯作者：
Grunberg, NE
影响因子：
2.9
作者：
McQuown, Susan C.;Belluzzi, James D.;Leslie, Frances M.
通讯作者：
Leslie, Frances M.
影响因子：
2.9
作者：
O'Dell, Laura E.;Torres, Oscar V.;Tejeda, Hugo A.
通讯作者：
Tejeda, Hugo A.
DOI：
10.1016/j.devbrainres.2004.08.004
发表时间：
2004-11-25
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Collins, SL;Montano, R;Izenwasser, S
通讯作者：
Izenwasser, S
影响因子：
3.6
作者：
Cruz, FC;DeLucia, R;Planeta, CS
通讯作者：
Planeta, CS