Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system.
Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system.
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DOI：
10.1186/s13014-021-01968-2
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发表时间：
2021-12-24
期刊：
影响因子：
--
通讯作者：
Ono K
中科院分区：
文献类型：
--
作者：
Hu N;Tanaka H;Kakino R;Yoshikawa S;Miyao M;Akita K;Isohashi K;Aihara T;Nihei K;Ono K
自2020年6月起，用于治疗不能切除的、局部晚期和复发的头颈癌的硼中子俘获疗法(BNCT)已被日本政府批准根据国家医疗保险进行报销。住友重工业株式会社(Sumitomo Heavy Industries，Ltd.)、NeuCure®剂量引擎开发了一种新的临床BNCT治疗计划系统。为了安全地将该系统应用于临床，对水模内模拟的中子通量和伽马射线剂量率与实验测量进行了比较。此外，为了验证和验证新的计划系统，将人头模型内的剂量分布与BNCT治疗计划系统血清和内部开发的蒙特卡罗剂量计算程序进行了比较。模拟结果与实验结果吻合较好，热中子注量率在5%以内，伽马射线剂量率在10%以内。头部模型内的剂量分布与血清和内部开发的剂量计算程序密切匹配，肿瘤的剂量计算程序在3%以内，大脑的剂量计算程序相差0.3G。
Boron neutron capture therapy (BNCT) for the treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck cancer has been approved by the Japanese government for reimbursement under the national health insurance as of June 2020. A new treatment planning system for clinical BNCT has been developed by Sumitomo Heavy Industries, Ltd. (Sumitomo), NeuCure® Dose Engine. To safely implement this system for clinical use, the simulated neutron flux and gamma ray dose rate inside a water phantom was compared against experimental measurements. Furthermore, to validate and verify the new planning system, the dose distribution inside an anthropomorphic head phantom was compared against a BNCT treatment planning system SERA and an in-house developed Monte Carlo dose calculation program. The simulated results closely matched the experimental results, within 5% for the thermal neutron flux and 10% for the gamma ray dose rate. The dose distribution inside the head phantom closely matched with SERA and the in-house developed dose calculation program, within 3% for the tumour and a difference of 0.3 Gyw for the brain.
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DOI：
10.1016/0360-3016(93)90533-2
发表时间：
1993-12-01
影响因子：
7
作者：
CODERRE, JA;MAKAR, MS;AMOLS, HI
通讯作者：
AMOLS, HI
影响因子：
3.8
作者：
Miften, Moyed;Olch, Arthur;Low, Daniel A.
通讯作者：
Low, Daniel A.
影响因子：
3.8
作者：
Goorley, JT;Kiger, WS;Zamenhof, RG
通讯作者：
Zamenhof, RG
影响因子：
3.9
作者：
Nigg, DW;Wheeler, FJ;Chadha, M
通讯作者：
Chadha, M
影响因子：
3.4
作者：
Coderre, JA;Chanana, AD;Slatkin, DN
通讯作者：
Slatkin, DN