Testing evolutionary explanations for the lifespan benefit of dietary restriction in Drosophila melanogaster
Testing evolutionary explanations for the lifespan benefit of dietary restriction in Drosophila melanogaster
复制标题
测试果蝇饮食限制对寿命益处的进化解释
DOI：
10.1101/2020.06.18.159731
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Savola E
中科院分区：
文献类型：
--
作者：
Savola E
饮食限制（DR），限制卡路里或特定营养素，延长不同类群的寿命。这种寿命的延长被解释为饮食介导的寿命和生殖之间的权衡变化，与生存资源稀缺的青睐。另一种进化假说认为，这种反应的选择性好处是维持繁殖。这一假设预测，寿命延长是良性实验室条件的副作用，其中DR个体更脆弱，无法处理额外的压力源，因此寿命延长应该在压力更大的条件下消失。我们测试饲养远交雌性果蝇10种不同的蛋白质：碳水化合物的饮食。苍蝇感染细菌病原体（嗜虫假单胞菌），受伤或无压力。我们监测了寿命、生育力和衰老指标。DR延长了寿命，减少了生殖，而与损伤和感染无关。这些结果不支持DR下的寿命延长是良性实验室条件的副作用。
Dietary restriction (DR), limiting calories or specific nutrients, extends lifespan across diverse taxa. This lifespan extension has been explained as diet-mediated changes in the trade-off between lifespan and reproduction, with survival favoured with scarce resources. Another evolutionary hypothesis suggests the selective benefit of the response is the maintenance of reproduction. This hypothesis predicts that lifespan extension is a side effect of benign laboratory conditions, where DR individuals are frailer and unable to deal with additional stressors, and thus lifespan extension should disappear under more stressful conditions. We tested this by rearing outbred femaleDrosophila melanogasteron 10 different protein:carbohydrate diets. Flies were either infected with a bacterial pathogen (Pseudomonas entomophila), injured or unstressed. We monitored lifespan, fecundity and ageing measures. DR extended lifespan and reduced reproduction irrespective of injury and infection. These results do not support lifespan extension under DR being a side effect of benign laboratory conditions.
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影响因子：
10.4
作者：
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通讯作者：
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影响因子：
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作者：
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