Hypothalamic stem cells control ageing speed partly through exosomal miRNAs.
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs.
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DOI：
10.1038/nature23282
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发表时间：
2017-08-03
期刊：
影响因子：
64.8
通讯作者：
Cai D
中科院分区：
文献类型：
--
作者：
Zhang Y;Kim MS;Jia B;Yan J;Zuniga-Hertz JP;Han C;Cai D
Hypothalamic control of aging was recently proposed, but the responsible mechanisms still remain unclear. Here, following the observation that aging of mice started with a substantial loss of hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1, we developed several mouse models with ablation of these hypothalamic cells, each of them consistently displaying an acceleration in aging-like physiological changes or shortening in lifespan. Conversely, aging retardation and lifespan extension were achieved in mid-aged mice when locally implanted with healthy hypothalamic stem/progenitor cells that were genetically engineered to survive from aging-related hypothalamic inflammatory microenvironment. Mechanistically, hypothalamic stem/progenitor cells greatly contributed to exosomal miRNAs in the cerebrospinal fluid which declined over aging, while central treatment with healthy hypothalamic stem/progenitor cells-secreted exosomes led to slowdown of aging. In conclusion, aging speed is controlled significantly by hypothalamic stem cells partially through release of exosomal miRNAs.
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