Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma.
Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma.
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DOI：
10.1016/j.canlet.2012.01.038
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发表时间：
2014-01-28
期刊：
影响因子：
9.7
通讯作者：
Rusyn, Ivan
中科院分区：
文献类型：
--
作者：
Pogribny, Igor P.;Rusyn, Ivan
肝细胞癌（HCC）是人类最致命和最常见的癌症之一。导致HCC发展的分子机制极其复杂，包括显著的遗传、基因组和表观遗传改变。本文综述了表观遗传学畸变在肝细胞癌发病机制中的作用，包括DNA甲基化、组蛋白修饰和microRNA表达的变化。它还强调，识别驱动细胞转化和促进HCC发展和进展的潜在表观遗传学改变对于理解肝癌发生机制、检测、治疗干预和预防至关重要。
Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in humans. The molecular mechanisms leading to the development of HCC are extremely complicated and consist of prominent genetic, genomic, and epigenetic alterations. This review summarizes the current knowledge of the role of epigenetic aberrations, including changes in DNA methylation, histone modifications, and expression of microRNAs in the pathogenesis of HCC. It also emphasizes that identification of the underlying epigenetic alterations that drive cell transformation and promote development and progression of HCC is crucially important for understanding mechanisms of hepatocarcinogenesis, its detection, therapeutic intervention, and prevention.
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影响因子：
8
作者：
Braconi, C.;Kogure, T.;Valeri, N.;Huang, N.;Nuovo, G.;Costinean, S.;Negrini, M.;Miotto, E.;Croce, C. M.;Patel, T.
通讯作者：
Patel, T.
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Di Leva G;Croce CM
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Ng, IOL
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通讯作者：
Moon, Woo Sung
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4.2
作者：
Corrales, FJ;Pérez-Mato, I;Mato, JM
通讯作者：
Mato, JM