Coordinate induction of acyl-CoA binding protein, fatty acid binding protein and peroxisomal beta-oxidation by peroxisome proliferators.
Coordinate induction of acyl-CoA binding protein, fatty acid binding protein and peroxisomal beta-oxidation by peroxisome proliferators.
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通过过氧化物酶体增殖剂协调诱导酰基辅酶A结合蛋白、脂肪酸结合蛋白和过氧化物酶体β-氧化。
DOI：
10.1016/0167-4889(93)90039-r
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Peterson,RE
中科院分区：
文献类型：
--
作者：
VandenHeuvel,JP;Sterchele,PF;Nesbit,DJ;Peterson,RE
酰基辅酶A结合蛋白（ACBP）和脂肪酸结合蛋白（FABP）是重要的细胞内脂质结合蛋白。本实验的目的是检验过氧化物酶体增殖物诱导大鼠肝细胞中ACBP的假设，如先前对FABP所示。两种结构不同的过氧化物酶体增殖剂全氟癸酸（PFDA）和氯贝酸（CPIB）的影响进行了研究，在原代大鼠肝细胞培养物中的化学成分确定的培养基。两种化合物以相似的方式改变原代大鼠肝细胞中的脂质代谢，尽管PFDA在诱导过氧化物酶体β-氧化方面比CPIB更有效。此外，PFDA和CPIB与长链脂肪酸竞争结合FABP，但不与长链酰基辅酶A酯竞争结合ACBP。在处理后48 h内，过氧化物酶体增殖物处理的肝细胞中ACBP和FABP的浓度相对于溶剂对照组升高。证据支持ACBP和FABP mRNA的增加是过氧化物酶体增殖物蛋白水平增加的原因。此外，过氧化物酶体增殖剂PFDA，全氟辛酸和环丙贝特诱导肝ACBP后，在体内给药的大鼠表明，这种现象并不限于在体外系统。因此，ACBP似乎是过氧化物酶体增殖物基因座的成员，过氧化物酶体增殖物基因座是一组脂质代谢蛋白，包括FABP，其受过氧化物酶体增殖物如纤维酸和全氟脂肪酸的调节。
Acyl-CoA binding protein (ACBP) and fatty acid binding protein (FABP) are important intracellular lipid binding proteins. The purpose of the present experiments was to test the hypothesis that peroxisome proliferators induce ACBP in rat hepatocytes as has been shown previously for FABP. The effects of two structurally dissimilar peroxisome proliferators perfluorodecanoic acid (PFDA) and clofibric acid (CPIB) were examined in primary rat hepatocyte cultures in a chemically defined media. Both compounds alter lipid metabolism in primary rat hepatocytes in a similar fashion, although PFDA is more potent than CPIB at inducing peroxisomal β-oxidation. In addition, PFDA and CPIB compete with long-chain fatty acids for binding to FABP but do not compete with long-chain acyl-CoA esters for binding to ACBP. The concentration of ACBP and FABP was increased in peroxisome proliferator-treated hepatocytes relative to vehicle controls within 48 h of treatment. Evidence is given to support increases in ACBP and FABP mRNA being the cause of the increased protein levels by peroxisome proliferators. In addition, the peroxisome proliferators PFDA, perfluorooctanoic acid and ciprofibrate induced hepatic ACBP following in vivo administration to rats indicating that this phenomena is not exclusive to in vitro systems. Therefore, ACBP appears to be a member of the peroxisome proliferator loci, a group of lipid metabolizing proteins, including FABP, which are regulated by peroxisome proliferators such as fibric acids and perfluorinated fatty acids.
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DOI：
10.3109/00365516609049052
发表时间：
1966-01-01
影响因子：
2.1
作者：
LAURELL, S
通讯作者：
LAURELL, S
诱导肝过氧化物酶体增殖的生化机制。
影响因子：
12.5
作者：
E. Lock;A. M. Mitchell;C. Elcombe
通讯作者：
C. Elcombe
不同类型细胞质脂肪酸结合蛋白的结构和功能特征。
DOI：
10.1016/0005-2760(91)90244-c
发表时间：
1991
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Jacques H. Veerkamp;R. A. Peeters;R.G.H.J. Maatman
通讯作者：
R.G.H.J. Maatman
降血脂过氧化物酶体增殖药物双（羧甲硫基）-1.10 癸烷（tiadenol 的二羧酸代谢物）被激活为酰基辅酶 A 硫酯。
DOI：
10.1016/0304-4165(90)90009-l
发表时间：
1990
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
A. Aarsland;R. Berge;J. Bremer;N. Aarsaether
通讯作者：
N. Aarsaether
将降血脂药物激活为酰基辅酶 A 硫酯。
DOI：
10.1042/bj2390781
发表时间：
1986
期刊：
The Biochemical journal
影响因子：
--
作者：
M. Bronfman;L. Amigo;M. Morales
通讯作者：
M. Morales