Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment.
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment.
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DOI：
10.1016/j.bbih.2020.100163
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Krupinski J
中科院分区：
文献类型：
--
作者：
Almeria M;Cejudo JC;Sotoca J;Deus J;Krupinski J
与新型冠状病毒（COVID-19）感染严重程度相关的认知表现尚不清楚。早期发现神经心理学表现可以降低随后发生不可逆损伤和进一步神经认知能力下降的风险。在我们的单中心队列研究中，我们纳入了所有年龄在 20 岁至 60 岁之间、已确诊的 COVID-19 感染的连续成年患者。神经心理学评估由同一位训练有素的神经心理学家于 2020 年 4 月 22 日至 6 月 16 日进行。先前已知认知障碍、任何中枢神经系统或精神疾病的患者均被排除。从医疗记录中提取人口统计、临床、药理学和实验室数据。 35 名患者符合纳入标准并被纳入该研究。与无症状患者相比，出现头痛、嗅觉丧失、味觉障碍、腹泻的患者以及需要氧疗的患者在记忆、注意力和执行功能分项测试中得分较低。头痛和临床缺氧的患者总体认知指数得分较低（P = 0.002，P = 0.010）。在记忆领域、注意力和语义流畅性 (2 [5.7%])、工作记忆和心理灵活性 (3 [8.6%]) 以及语音流畅性 (4 [11.4%]) 中观察到 T 得分低于 30。有认知问题的患者的焦虑和抑郁得分较高（P = 0.047，P = 0.008）。在我们的 COVID-19 患者队列中，神经系统表现很常见，包括认知障碍。感染、腹泻和氧疗期间的神经症状是神经认知障碍的危险因素。认知问题与焦虑和抑郁有关。与 COVID-19 感染相关的神经心理缺陷见于注意力、记忆和执行功能领域。 COVID-19 感染期间出现的神经系统症状是认知缺陷的危险因素。氧疗、头痛和腹泻是与神经心理学测试表现不佳相关的症状。 COVID-19 患者的认知抱怨与焦虑和抑郁症状相关。
Cognitive manifestations associated with the severity of a novel coronavirus (COVID-19) infection are unknown. An early detection of neuropsychological manifestations could modify the risk of subsequent irreversible impairment and further neurocognitive decline. In our single-center cohort study, we included all consecutive adult patients, aged between 20 and 60 years old with confirmed COVID-19 infection. Neuropsychological assessment was performed by the same trained neuropsychologist from April, 22nd through June 16th, 2020. Patients with previous known cognitive impairment, any central nervous system or psychiatric disease were excluded. Demographic, clinical, pharmacological and laboratory data were extracted from medical records. Thirty-five patients met inclusion criteria and were included in the study. Patients presenting headache, anosmia, dysgeusia, diarrhea and those who required oxygen therapy had lower scores in memory, attention and executive function subtests as compared to asymptomatic patients. Patients with headache and clinical hypoxia scored lower in the global Cognitive Index (P = 0.002, P = 0.010). A T score lower than 30 was observed in memory domains, attention and semantic fluency (2 [5.7%]) in working memory and mental flexibility (3 [8.6%]) and in phonetic fluency (4 [11.4%]). Higher scores in anxiety and depression (P = 0.047, P = 0.008) were found in patients with cognitive complaints. In our cohort of COVID-19 patients neurologic manifestations were frequent, including cognitive impairment. Neurological symptoms during infection, diarrhea and oxygen therapy were risk factors for neurocognitive impairment. Cognitive complaints were associated with anxiety and depression. Neuropsychological deficits related to COVID-19 infection were seen in attention, memory and executive function domains. Presenting neurological symptoms during COVID-19 infection were risk factors for cognitive deficit. Oxygen therapy, headache and diarrhea were symptoms associated to poor performance in neuropsychological tests. Cognitive complains in patients with COVID-19 were associated with anxiety and depressive symptoms.
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影响因子：
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作者：
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通讯作者：
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DOI：
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