Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism.
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DOI：
10.1016/j.chom.2015.03.006
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发表时间：
2015-05-13
影响因子：
30.3
通讯作者：
Chang EB
中科院分区：
文献类型：
--
作者：
Leone V;Gibbons SM;Martinez K;Hutchison AL;Huang EY;Cham CM;Pierre JF;Heneghan AF;Nadimpalli A;Hubert N;Zale E;Wang Y;Huang Y;Theriault B;Dinner AR;Musch MW;Kudsk KA;Prendergast BJ;Gilbert JA;Chang EB
昼夜节律钟和代谢密不可分，其中中枢和肝脏昼夜节律钟协调代谢事件以响应光暗和睡眠-觉醒周期。我们揭示了维持宿主昼夜节律的另一个关键因素，即肠道微生物组。尽管持续存在明暗信号，但喂食低脂肪或高脂肪饮食的无菌小鼠表现出明显受损的中枢和肝脏生物钟基因表达，并且与常规饲养的小鼠相比，体重没有增加。对常规饲养小鼠肠道微生物群的检查显示，微生物结构和功能的昼夜变化取决于饮食组成。此外，在低脂肪或高脂肪饲养下诱导的特定微生物代谢产物（特别是短链脂肪酸，但不是硫化氢）直接调节肝细胞内的昼夜节律钟基因表达。这些结果强调了微生物衍生的代谢物调节或改变中枢和肝脏昼夜节律和宿主代谢功能的能力，后者是在摄入西化饮食后。
Circadian clocks and metabolism are inextricably intertwined, where central and hepatic circadian clocks coordinate metabolic events in response to light-dark and sleep-wake cycles. We reveal an additional key element involved in maintaining host circadian rhythms, the gut microbiome. Despite persistence of light-dark signals, germ-free mice fed low or high fat diets exhibit markedly impaired central and hepatic circadian clock gene expression and do not gain weight compared to conventionally-raised counterparts. Examination of gut microbiota in conventionally-raised mice showed differential diurnal variation in microbial structure and function dependent upon dietary composition. Additionally, specific microbial metabolites induced under low or high fat feeding, particularly short chain fatty acids, but not hydrogen sulfide, directly modulate circadian clock gene expression within hepatocytes. These results underscore the ability of microbially-derived metabolites to regulate or modify central and hepatic circadian rhythm and host metabolic function, the latter following intake of a Westernized diet.
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1126/science.1241214
发表时间：
2013-09-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ridaura VK;Faith JJ;Rey FE;Cheng J;Duncan AE;Kau AL;Griffin NW;Lombard V;Henrissat B;Bain JR;Muehlbauer MJ;Ilkayeva O;Semenkovich CF;Funai K;Hayashi DK;Lyle BJ;Martini MC;Ursell LK;Clemente JC;Van Treuren W;Walters WA;Knight R;Newgard CB;Heath AC;Gordon JI
通讯作者：
Gordon JI
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
影响因子：
64.5
作者：
Balsalobre, A;Damiola, F;Schibler, U
通讯作者：
Schibler, U
影响因子：
2.9
作者：
Kartha, Reena V.;Zhou, Jie;Schroeder, Henning
通讯作者：
Schroeder, Henning