Contour integration impairment in schizophrenia and first episode psychosis: state or trait?
Contour integration impairment in schizophrenia and first episode psychosis: state or trait?
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DOI：
10.1016/j.schres.2014.09.028
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发表时间：
2014-11
影响因子：
4.5
通讯作者：
Silverstein, Steven M.
中科院分区：
文献类型：
--
作者：
Feigenson, Keith A.;Keane, Brian P.;Roche, Matthew W.;Silverstein, Steven M.
轮廓整合是一个基本的视觉过程，恢复对象的结构表示空间分离的边缘元素作为一个连续的轮廓或形状边界。临床上稳定的精神分裂症患者的轮廓整合能力一再被证明受损，但目前尚不清楚这一过程是否因临床状态而异，或者是否早在精神病首次发作时就出现了。为了考虑这些问题，我们对慢性精神分裂症患者和首发精神病患者进行了轮廓整合测试。该测试进行了两次，一次是在短期精神病住院治疗时，一次是在出院时。还在相同的时间点对匹配良好的健康对照组进行了测试。我们发现，随着时间的推移，所有组的轮廓整合性能提高到相同的程度，表明没有恢复效果超过正常的实践效果。此外，精神分裂症组表现出较差的轮廓整合比对照组和第一次发作组表现出中间的性能，不能从其他组区分。这些结果表明，轮廓整合能力不随临床状态的短期变化而变化，随着精神病发作次数的增加，轮廓整合能力可能会进一步受损。
Contour integration is a fundamental visual process that recovers object structure by representing spatially separated edge elements as a continuous contour or shape boundary. Clinically stable persons with schizophrenia have repeatedly been shown to be impaired at contour integration but it is unclear whether this process varies with clinical state or whether it arises as early as the first episode of psychosis. To consider these issues, we administered a contour integration test to persons with chronic schizophrenia and to those with a first episode of psychosis. The test was administered twice—once at admission to short term psychiatric hospitalization and once again at discharge. A well-matched healthy control group was also tested across the same time points. We found that contour integration performance improved to the same degree in all groups over time, indicating that there were no recovery effects over and above normal practice effects. Moreover, the schizophrenia group demonstrated poorer contour integration than the control group and the first episode group exhibited intermediate performance that could not be distinguished from the other groups. These results suggest that contour integration ability does not vary as a function of short-term changes in clinical state, and that it may become further impaired with an increased number of psychotic episodes.
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