Skin γδ T Cells and Their Function in Wound Healing.

Skin γδ T Cells and Their Function in Wound Healing.
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皮肤 γT 细胞及其在伤口愈合中的功能

DOI:
10.3389/fimmu.2022.875076
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发表时间:
2022
影响因子:
7.3
通讯作者:
Luo, Gaoxing
Luo, Gaoxing
中科院分区:
医学2区
文献类型:
--
作者:
Hu, Wengang;Shang, Ruoyu;Yang, Jiacai;Chen, Cheng;Liu, Zhihui;Liang, Guangping;He, Weifeng;Luo, Gaoxing

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对于皮肤免疫系统来说,γδT细胞是重要的组成部分,有助于防御皮肤的损伤和感染。与传统的αβ T细胞相比,γδ T细胞具有自己的分化、发育和激活特性。在成年小鼠中,树突状表皮T细胞(DETC)、Vγ4和Vγ6γδT细胞是皮肤的主要亚群,它们之间的协调和相互作用在伤口修复中发挥着至关重要的作用。为了对 γδ T 细胞有一个清晰的概述,本文概述了它们的衍生、发育、定植和激活,并重点介绍了它们在急性和慢性伤口愈合中的功能及其潜在机制。本文的目的是为人类表皮 γδ T 细胞的研究和皮肤康复的潜在治疗提供线索。
For the skin immune system, γδ T cells are important components, which help in defensing against damage and infection of skin. Compared to the conventional αβ T cells, γδ T cells have their own differentiation, development and activation characteristics. In adult mice, dendritic epidermal T cells (DETCs), Vγ4 and Vγ6 γδ T cells are the main subsets of skin, the coordination and interaction among them play a crucial role in wound repair. To get a clear overview of γδ T cells, this review synopsizes their derivation, development, colonization and activation, and focuses their function in acute and chronic wound healing, as well as the underlining mechanism. The aim of this paper is to provide cues for the study of human epidermal γδ T cells and the potential treatment for skin rehabilitation.
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