Skin microbiota-host interactions.

Skin microbiota-host interactions.
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DOI:
10.1038/nature25177
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发表时间:
2018-01-24
期刊:
影响因子:
64.8
通讯作者:
Belkaid Y
Belkaid Y
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Chen YE;Fischbach MA;Belkaid Y

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皮肤是一个复杂而动态的生态系统,由细菌,古细菌,真菌和病毒居住。这些微生物统称为皮肤微生物群是皮肤生理和免疫的基础。皮肤微生物和宿主之间的相互作用可以沿着互利共生和致病性之间的连续体。在这篇综述中,我们强调宿主-微生物相互作用如何严重依赖于上下文,包括免疫激活状态,宿主遗传易感性,屏障状态,微生物定位和微生物-微生物相互作用。我们专注于环境如何塑造皮肤微生物和宿主之间的复杂对话,以及这种对话对健康和疾病的影响。
The skin is a complex and dynamic ecosystem that is inhabited by bacteria, archaea, fungi and viruses. These microbes—collectively referred to as the skin microbiota—are fundamental to skin physiology and immunity. Interactions between skin microbes and the host can fall anywhere along the continuum between mutualism and pathogenicity. In this Review, we highlight how host–microbe interactions depend heavily on context, including the state of immune activation, host genetic predisposition, barrier status, microbe localization, and microbe–microbe interactions. We focus on how context shapes the complex dialogue between skin microbes and the host, and the consequences of this dialogue for health and disease.
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发表时间: 2016-01-01
期刊: SKIN BARRIER FUNCTION
影响因子: --
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