Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells.
Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells.
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DOI：
10.1038/nsmb.1794
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发表时间：
2010-05
影响因子：
16.8
通讯作者：
中科院分区：
文献类型：
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Genome-wide occupancy profiles of five components of the RNA Polymerase III (Pol III) machinery in human cells identified the expected tRNA and non-coding RNA targets and revealed many additional Pol III-associated loci, mostly near SINEs. Several genes are targets of an alternative TFIIIB containing Brf2 instead of Brf1 and have extremely low levels of TFIIIC. Strikingly, expressed Pol III genes, unlike non-expressed Pol III genes, are situated in regions with a pattern of histone modifications associated with functional Pol II promoters. TFIIIC alone associates with numerous ETC loci, via the B box or a novel motif. ETCs are often near CTCF binding sites, suggesting a potential role in chromosome organization. Our results suggest that human Pol III complexes associate preferentially with regions near functional Pol II promoters and that TFIIIC-mediated recruitment of TFIIIB is regulated in a locus-specific manner.
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DOI：
10.1093/bioinformatics/btp472
发表时间：
2009-10-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Nicol JW;Helt GA;Blanchard SG Jr;Raja A;Loraine AE
通讯作者：
Loraine AE
影响因子：
10.5
作者：
D'Ambrosio, Claudio;Schmidt, Christine Katrin;Uhlmann, Frank
通讯作者：
Uhlmann, Frank
影响因子：
11.4
作者：
Harismendy, O;Gendrel, CG;Lefebvre, O
通讯作者：
Lefebvre, O
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
14.9
作者：
Bortolin-Cavaillé ML;Dance M;Weber M;Cavaillé J
通讯作者：
Cavaillé J