PRMT5 acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling in murine gastric tumorigenesis.
PRMT5 acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling in murine gastric tumorigenesis.
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PRMT5 通过抑制小鼠胃肿瘤发生中的 Wnt/β-catenin 信号传导来充当肿瘤抑制剂
DOI：
10.7150/ijbs.71581
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发表时间：
2022
影响因子：
9.2
通讯作者：
Teng, Yan
中科院分区：
文献类型：
--
作者：
Tang, Yuling;Dong, Lei;Zhang, Chong;Li, Xiubin;Li, Rongyu;Lin, Huisang;Qi, Yini;Tang, Mingchuan;Peng, Yanli;Liu, Chuan;Zhou, Jian;Hou, Ning;Liu, Wenjia;Yang, Guan;Yang, Xiao;Teng, Yan
先前的研究表明，蛋白质精氨酸甲基转移酶5（PRMT5）在胃癌中的体内功能在胃肿瘤中。肠道胃癌4个月以内。 （2/10）PRMT5突变体最终在8个月的胃癌中发展成侵入性胃癌，这是由PRMT5损失引起的LGR5+干细胞的增加，这是胃肿瘤的摄入量的大多数元素，这是胃肿瘤的一致性。 PRMT5突变胃癌显示出激活Wnt/β-catenin信号传导。
Previous studies have demonstrated the in vitro oncogenic role of protein arginine methyltransferase 5 (PRMT5) in gastric cancer cell lines. The in vivo function of PRMT5 in gastric tumorigenesis, however, is still unexplored. Here, we showed that Prmt5 deletion in mouse gastric epithelium resulted in spontaneous tumorigenesis in gastric antrum. All Prmt5-deficient mice displayed intestinal-type gastric cancer within 4 months of age. Of note, 20% (2/10) of Prmt5 mutants finally developed into invasive gastric cancer by 8 months of age. Gastric cancer caused by PRMT5 loss exhibited the increase in Lgr5+ stem cells, which are proposed to contribute to both the gastric tumorigenesis and progression in mouse models. Consistent with the notion that Lgr5 is the target of Wnt/β-catenin signaling, whose activation is the most predominant driver for gastric tumorigenesis, Prmt5 mutant gastric cancer showed the activation of Wnt/β-Catenin signaling. Furthermore, in human gastric cancer samples, PRMT5 deletion and downregulation were frequently observed and associated with the poor prognosis. We propose that as opposed to the tumor-promoting role of PRMT5 well-established in the progression of various cancer types, PRMT5 functions as a tumor suppressor in vivo, at least during gastric tumor formation.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
DOI：
10.1083/jcb.200311021
发表时间：
2004-07-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Blache P;van de Wetering M;Duluc I;Domon C;Berta P;Freund JN;Clevers H;Jay P
通讯作者：
Jay P
影响因子：
21.3
作者：
Leushacke, Marc;Tan, Si Hui;Barker, Nick
通讯作者：
Barker, Nick
影响因子：
50.3
作者：
Ishimoto, Takatsugu;Nagano, Osamu;Saya, Hideyuki
通讯作者：
Saya, Hideyuki
DOI：
10.1111/apm.1965.64.1.31
发表时间：
1965-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
LAUREN, P
通讯作者：
LAUREN, P