Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells.
Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells.
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DOI：
10.3389/fimmu.2018.01478
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发表时间：
2018
影响因子：
7.3
通讯作者：
Provine NM
中科院分区：
文献类型：
--
作者：
Garner LC;Klenerman P;Provine NM
粘膜相关不变 T (MAIT) 细胞和不变自然杀伤 T (iNKT) 细胞是先天性 T 细胞，在先天免疫和适应性免疫之间发挥作用。它们表达半不变 T 细胞受体 (TCR)，并识别分别与 MHC I 类分子 MR1 和 CD1d 结合的非常规非肽配体。 MAIT 细胞和 iNKT 细胞表现出效应记忆表型，并且在肝脏和粘膜部位富集。在人类中，MAIT 细胞的频率使 iNKT 细胞的频率相形见绌，而在实验室小鼠品系中，情况恰恰相反。通过 TCR 或细胞因子依赖性途径激活后，MAIT 细胞和 iNKT 细胞迅速产生细胞因子并表现出直接的细胞毒活性。因此，它们对于有效的免疫至关重要，并且它们的频率和功能的改变与许多传染性、炎症和恶性疾病有关。由于 iNKT 细胞在小鼠体内含量丰富且试剂开发较早，因此 iNKT 细胞比 MAIT 细胞得到了更广泛的研究。这导致人们常规使用 iNKT 细胞作为 MAIT 细胞研究的参考群体，并且这种方法已被证明非常富有成效。然而，MAIT 细胞和 iNKT 细胞显示出经常被忽视的重要表型、功能和发育差异。随着最近新工具（最重要的是 MR1 四聚体）的出现，现在可以直接研究 MAIT 细胞以了解其生物学特性。因此，比较MAIT细胞和iNKT细胞的表型、发育和功能是适时的。在这篇综述中，我们重点介绍了 MAIT 细胞与 iNKT 细胞相似或不同的关键领域。此外，我们还讨论了 MAIT 细胞领域未来研究的重要途径，特别是在与 iNKT 细胞的比较已证明信息量较少的情况下。
Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity. They express semi-invariant T cell receptors (TCRs) and recognize unconventional non-peptide ligands bound to the MHC Class I-like molecules MR1 and CD1d, respectively. MAIT cells and iNKT cells exhibit an effector-memory phenotype and are enriched within the liver and at mucosal sites. In humans, MAIT cell frequencies dwarf those of iNKT cells, while in laboratory mouse strains the opposite is true. Upon activation via TCR- or cytokine-dependent pathways, MAIT cells and iNKT cells rapidly produce cytokines and show direct cytotoxic activity. Consequently, they are essential for effective immunity, and alterations in their frequency and function are associated with numerous infectious, inflammatory, and malignant diseases. Due to their abundance in mice and the earlier development of reagents, iNKT cells have been more extensively studied than MAIT cells. This has led to the routine use of iNKT cells as a reference population for the study of MAIT cells, and such an approach has proven very fruitful. However, MAIT cells and iNKT cells show important phenotypic, functional, and developmental differences that are often overlooked. With the recent availability of new tools, most importantly MR1 tetramers, it is now possible to directly study MAIT cells to understand their biology. Therefore, it is timely to compare the phenotype, development, and function of MAIT cells and iNKT cells. In this review, we highlight key areas where MAIT cells show similarity or difference to iNKT cells. In addition, we discuss important avenues for future research within the MAIT cell field, especially where comparison to iNKT cells has proven less informative.
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DOI：
10.1084/jem.20171739
发表时间：
2018-02-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ben Youssef G;Tourret M;Salou M;Ghazarian L;Houdouin V;Mondot S;Mburu Y;Lambert M;Azarnoush S;Diana JS;Virlouvet AL;Peuchmaur M;Schmitz T;Dalle JH;Lantz O;Biran V;Caillat-Zucman S
通讯作者：
Caillat-Zucman S
影响因子：
5.8
作者：
Carreño LJ;Saavedra-Ávila NA;Porcelli SA
通讯作者：
Porcelli SA
影响因子：
64.5
作者：
Brodin P;Jojic V;Gao T;Bhattacharya S;Angel CJ;Furman D;Shen-Orr S;Dekker CL;Swan GE;Butte AJ;Maecker HT;Davis MM
通讯作者：
Davis MM
影响因子：
15.3
作者：
Benlagha, K;Weiss, A;Beavis, A;Teyton, L;Bendelac, A
通讯作者：
Bendelac, A
影响因子：
7.3
作者：
Booth JS;Salerno-Goncalves R;Blanchard TG;Patil SA;Kader HA;Safta AM;Morningstar LM;Czinn SJ;Greenwald BD;Sztein MB
通讯作者：
Sztein MB