Natural products targeting glycolysis in cancer.
Natural products targeting glycolysis in cancer.
复制标题
DOI：
10.3389/fphar.2022.1036502
复制
发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
癌症中存在许多能量代谢途径，包括糖酵解、氨基酸代谢、脂肪酸氧化和线粒体呼吸。肿瘤细胞主要通过糖酵解产生能量，维持肿瘤细胞在有氧条件下的生长和生物合成。天然产物调节糖酵解的许多步骤，利用天然产物靶向糖酵解是治疗癌症的一种有前途的方法。在这篇综述中，我们举例说明了糖酵解与肿瘤的关系，展示了已发现的针对糖酵解用于癌症治疗的天然产物，并阐明了它们的作用机制。天然产物，如主要存在于红葡萄皮中的白藜芦醇，从膨胀甘草根中提取的甘草酮A，以及主要来自植物或动物材料的鸦胆子油和鸦胆子醇，可以通过靶向糖酵解酶和相关蛋白质、癌基因和许多糖酵解信号蛋白来影响癌症的糖酵解途径。了解天然产物如何调节有氧糖酵解将有助于阐明这些产品可用作治疗药物以抑制癌细胞生长和调节细胞代谢的机制。系统评审注册：https://pubmed.ncbi.nlm.nih.gov/，https://clinicaltrials.gov/，http://lib.zzu.edu.cn/
Many energy metabolism pathways exist in cancer, including glycolysis, amino acid metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate energy through glycolysis to maintain growth and biosynthesis of tumor cells under aerobic conditions. Natural products regulate many steps in glycolysis and targeting glycolysis using natural products is a promising approach to cancer treatment. In this review, we exemplify the relationship between glycolysis and tumors, demonstrate the natural products that have been discovered to target glycolysis for cancer treatment and clarify the mechanisms involved in their actions. Natural products, such as resveratrol mostly found in red grape skin, licochalcone A derived from root of Glycyrrhiza inflate, and brusatol found in Brucea javanica and Brucea mollis, largely derived from plant or animal material, can affect glycolysis pathways in cancer by targeting glycolytic enzymes and related proteins, oncogenes, and numerous glycolytic signal proteins. Knowledge of how natural products regulate aerobic glycolysis will help illuminate the mechanisms by which these products can be used as therapeutics to inhibit cancer cell growth and regulate cellular metabolism. Systematic Review Registration: https://pubmed.ncbi.nlm.nih.gov/, https://clinicaltrials.gov/, http://lib.zzu.edu.cn/
登录
查看更多内容
DOI：
10.18632/aging.101483
发表时间：
2018-08-23
期刊：
Aging
影响因子：
--
作者：
Bonuccelli G;Sotgia F;Lisanti MP
通讯作者：
Lisanti MP
影响因子：
5.6
作者：
Fang ZY;Zhang M;Liu JN;Zhao X;Zhang YQ;Fang L
通讯作者：
Fang L
影响因子：
5.6
作者：
Carrasco-Pozo, Catalina;Kah Ni Tan;Avery, Vicky M.
通讯作者：
Avery, Vicky M.
影响因子：
5.4
作者：
Daddiouaissa, Djabir;Amid, Azura;Elnour, Ahmed A. M.
通讯作者：
Elnour, Ahmed A. M.
影响因子：
5.6
作者：
Akter R;Afrose A;Rahman MR;Chowdhury R;Nirzhor SSR;Khan RI;Kabir MT
通讯作者：
Kabir MT