Lymphangiogenesis and cancer metastasis.
Lymphangiogenesis and cancer metastasis.
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DOI：
10.1111/j.1582-4934.2009.00834.x
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发表时间：
2009-08
影响因子：
5.3
通讯作者：
Detmar M
中科院分区：
文献类型：
--
作者：
Mumprecht V;Detmar M
转移是大多数肿瘤类型的特征，也是大多数癌症死亡的原因。许多肿瘤类型，包括黑色素瘤、乳腺癌和前列腺癌，首先通过淋巴管转移到其区域淋巴结。虽然淋巴结转移和患者生存时间缩短之间的联系在几十年前就已经建立起来，但淋巴系统在癌症转移中的积极参与直到最近才被解开，在淋巴管的分子标记物被确定之后。越来越多的证据表明，肿瘤诱导的淋巴管生成是淋巴结转移的预测指标，也可能是预防转移的靶点。本文综述了目前对肿瘤淋巴管生成的认识，用于预防和治疗转移性疾病的抗淋巴管生成策略，用于预后和转移诊断的淋巴管生成定量以及用于评估淋巴管、引流和淋巴结的体内成像技术。
Metastasis is a characteristic trait of most tumour types and the cause for the majority of cancer deaths. Many tumour types, including melanoma and breast and prostate cancers, first metastasize via lymphatic vessels to their regional lymph nodes. Although the connection between lymph node metastases and shorter survival times of patients was made decades ago, the active involvement of the lymphatic system in cancer, metastasis has been unravelled only recently, after molecular markers of lymphatic vessels were identified. A growing body of evidence indicates that tumour-induced lymphangiogenesis is a predictive indicator of metastasis to lymph nodes and might also be a target for prevention of metastasis. This article reviews the current understanding of lymphangiogenesis in cancer anti-lymphangiogenic strategies for prevention and therapy of metastatic disease, quantification of lymphangiogenesis for the prognosis and diagnosis of metastasis and in vivo imaging technologies for the assessment of lymphatic vessels, drainage and lymph nodes.
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影响因子：
5
作者：
Choi, SH;Kono, Y;Mattrey, RF
通讯作者：
Mattrey, RF
影响因子：
--
作者：
Blanchard, DK;Donohue, JH;Grant, CS
通讯作者：
Grant, CS
影响因子：
1.7
作者：
Doeden, Katie;Ma, Zhihai;Dadras, Soheil S.
通讯作者：
Dadras, Soheil S.
影响因子：
7.8
作者：
Banerji, S;Ni, J;Wang, S X;Clasper, S;Su, J;Tammi, R;Jones, M;Jackson, D G
通讯作者：
Jackson, D G
影响因子：
3.4
作者：
Cserni, G
通讯作者：
Cserni, G