Spatial tuning to sound-source azimuth in the inferior colliculus of unanesthetized rabbit.
Spatial tuning to sound-source azimuth in the inferior colliculus of unanesthetized rabbit.
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未麻醉兔子下丘声源方位角的空间调谐。
DOI：
10.1152/jn.00532.2011
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发表时间：
2011
影响因子：
2.5
通讯作者：
Kim,DuckO
中科院分区：
文献类型：
--
作者：
Kuwada,Shigeyuki;Bishop,Brian;Alex,Caitlin;Condit,DanielW;Kim,DuckO
尽管几十年来一直致力于研究下丘（IC）神经元对声源方位角的调节，但由于之前没有研究在非麻醉条件下在大范围刺激水平下对360°全方位方位角的调节进行研究，因此仍然存在许多未解之谜。此外，方位角调整对双耳和对侧耳刺激在全方位角范围内和广泛变化的刺激水平的比较以前没有报道。为了填补这一空白，我们利用虚拟听觉空间刺激，在双耳和对侧耳刺激水平高于神经阈值10-50分贝的刺激水平下，在未麻醉的兔子的IC中进行了300°方位角范围内的方位调节研究。本研究为方位神经编码提供了系统证据。我们发现：1)IC神经元的矢量强度和矢量角度分别在前35%和前15%中存在水平容忍方位调谐；2)对侧声场双耳促进和同侧声场双耳抑制使双耳在高刺激水平下对双耳刺激保持方位调谐；3)双耳刺激的方位调谐方向主要在对侧声场，随着刺激水平的增加，其中心向- 90°方向横向移动；4)在10 dB时，双耳和对侧刺激的方位调谐相似，表明其是由单耳机制介导的；5)在较高的刺激水平下，对侧耳刺激的方位调谐严重退化。这些发现为理解声源方位定位的神经机制奠定了基础。
Despite decades of research devoted to the study of inferior colliculus (IC) neurons' tuning to sound-source azimuth, there remain many unanswered questions because no previous study has examined azimuth tuning over a full range of 360° azimuths at a wide range of stimulus levels in an unanesthetized preparation. Furthermore, a comparison of azimuth tuning to binaural and contralateral ear stimulation over ranges of full azimuths and widely varying stimulus levels has not previously been reported. To fill this void, we have conducted a study of azimuth tuning in the IC of the unanesthetized rabbit over a 300° range of azimuths at stimulus levels of 10–50 dB above neural threshold to both binaural and contralateral ear stimulation using virtual auditory space stimuli. This study provides systematic evidence for neural coding of azimuth. We found the following:1) level-tolerant azimuth tuning was observed in the top 35% regarding vector strength and in the top 15% regarding vector angle of IC neurons;2) preserved azimuth tuning to binaural stimulation at high stimulus levels was created as a consequence of binaural facilitation in the contralateral sound field and binaural suppression in the ipsilateral sound field;3) the direction of azimuth tuning to binaural stimulation was primarily in the contralateral sound field, and its center shifted laterally toward −90° with increasing stimulus level;4) at 10 dB, azimuth tuning to binaural and contralateral stimulation was similar, indicating that it was mediated by monaural mechanisms; and5) at higher stimulus levels, azimuth tuning to contralateral ear stimulation was severely degraded. These findings form a foundation for understanding neural mechanisms of localizing sound-source azimuth.
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DOI：
10.1136/bmj.294.6564.91
发表时间：
1987
期刊：
British Medical Journal (Clinical research ed.)
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作者：
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DOI：
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发表时间：
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影响因子：
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