Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors.
Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors.
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DOI：
10.1002/oby.22166
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Novak CM
中科院分区：
文献类型：
--
作者：
Gavini CK;Britton SL;Koch LG;Novak CM
活动产热和能量消耗（EE）在本质上瘦的大鼠（高容量跑步者，HCR）中升高，并且还受到腹内侧下丘脑（VMH）中黑皮质素受体激活的刺激。在这里，我们确定了HCR是否比低能力跑步者（LCR）对EE活动的中枢调节更敏感。HCR和LCR大鼠接受VMH内微量注射Melanotan II（MTII），一种混合黑皮质素受体激动剂。比较EE、呼吸交换率（RER）、活动EE、肌肉热量、去甲肾上腺素周转率（NETO）和肌肉能量调节剂的变化。HCR对VMH MTII内诱导的EE、EE活性、NETO对某些肌肉亚组的变化以及某些能量调节剂的肌肉mRNA表达的反应更明显。虽然HCR有较高的肌肉活动产热，有限的MTII诱导的肌肉产热在活动过程中的调制中看到的LCR。天生瘦、高容量的大鼠表型对中枢黑皮质素刺激EE活动和使用脂肪作为燃料的反应增强。这可能是由交感神经流出到骨骼肌驱动的，MTII后交感神经流出增加。中枢黑皮质素受体激活也改变了骨骼肌能量调节剂，其方式与EE升高和RER降低一致。
Activity thermogenesis and energy expenditure (EE) are elevated in intrinsically lean rats (high-capacity runners, HCR), and are also stimulated by melanocortin receptor activation in the ventromedial hypothalamus (VMH). Here, we determined if HCR are more responsive to central modulation of activity EE compared to low-capacity runners (LCR). HCR and LCR rats received intra-VMH microinjections of Melanotan II (MTII), a mixed melanocortin receptor agonist. Changes in EE, respiratory exchange ratio (RER), activity EE, muscle heat, norepinephrine turnover (NETO), and muscle energetic modulators were compared. HCR were significantly more responsive to intra-VMH MTII-induced changes in EE, activity EE, NETO to some muscle subgroups, and muscle mRNA expression of some energetic modulators. Though HCR had high muscle activity thermogenesis, limited MTII-induced modulation of muscle thermogenesis during activity was seen in LCR only. An inherently lean, high-capacity rat phenotype showed elevated response to central melanocortin stimulation of activity EE and use of fat as fuel. This may be driven by sympathetic outflow to skeletal muscle, which was elevated after MTII. Central melanocortin receptor activation also altered skeletal muscle energetic modulators in a manner consistent with elevated EE and lowered RER.
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影响因子：
15.9
作者：
Nogueiras, Ruben;Wiedmer, Petra;Tschoep, Matthias H.
通讯作者：
Tschoep, Matthias H.
影响因子：
64.8
作者：
Minokoshi, Y;Kim, YB;Kahn, BB
通讯作者：
Kahn, BB
影响因子：
3.3
作者：
Miyaki, T.;Fujikawa, T.;Inoue, K.
通讯作者：
Inoue, K.
影响因子：
5.5
作者：
Gavini, Chaitanya K.;Jones, William C., II;Novak, Colleen M.
通讯作者：
Novak, Colleen M.
DOI：
10.1111/j.1365-201x.2005.01467.x
发表时间：
2005-08-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
Levine, JA;Kotz, CM
通讯作者：
Kotz, CM