The doublesex gene regulates dimorphic sexual and aggressive behaviors in Drosophila.
The doublesex gene regulates dimorphic sexual and aggressive behaviors in Drosophila.
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DOI：
10.1073/pnas.2201513119
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发表时间：
2022-09-13
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
Animals display dimorphic sexual and aggressive behaviors. In Drosophila, the doublesex (dsx) gene encodes male-specific DsxM and female-specific DsxF transcription factors and controls sexual development and behaviors. In mammals, dsx-related Dmrt genes direct the differentiation of gonads that produce sex hormones, controlling both the organization and activation of neural circuits underlying sexually dimorphic behaviors. In this study, we find that sex-specific Dsx isoforms promote distinct sexual behaviors in both sexes, and oppositely regulate aggression to establish male-biased aggressiveness. We further show that Dsx functions both developmentally and acutely in sex-specific interneurons that control these behaviors. Our results reveal that a conserved sex-determination gene plays both organizational and activational roles in sexually dimorphic behaviors. Most animal species display dimorphic sexual behaviors and male-biased aggressiveness. Current models have focused on the male-specific product from the fruitless (fruM) gene, which controls male courtship and male-specific aggression patterns in fruit flies, and describe a male-specific mechanism underlying sexually dimorphic behaviors. Here we show that the doublesex (dsx) gene, which expresses male-specific DsxM and female-specific DsxF transcription factors, functions in the nervous system to control both male and female sexual and aggressive behaviors. We find that Dsx is not only required in central brain neurons for male and female sexual behaviors, but also functions in approximately eight pairs of male-specific neurons to promote male aggressiveness and approximately two pairs of female-specific neurons to inhibit female aggressiveness. DsxF knockdown females fight more frequently, even with males. Our findings reveal crucial roles of dsx, which is broadly conserved from worms to humans, in a small number of neurons in both sexes to establish dimorphic sexual and aggressive behaviors.
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影响因子：
3.3
作者：
Dionne H;Hibbard KL;Cavallaro A;Kao JC;Rubin GM
通讯作者：
Rubin GM
影响因子：
64.5
作者：
Asahina K;Watanabe K;Duistermars BJ;Hoopfer E;González CR;Eyjólfsdóttir EA;Perona P;Anderson DJ
通讯作者：
Anderson DJ
开发过程中求爱巡回赛的毫无结果的曲调灵活性。
影响因子：
7.7
作者：
Chen J;Jin S;Chen D;Cao J;Ji X;Peng Q;Pan Y
通讯作者：
Pan Y
影响因子：
16.2
作者：
Kimura, Ken-ichi;Hachiya, Tomoaki;Yamamoto, Daisuke
通讯作者：
Yamamoto, Daisuke
影响因子：
7.7
作者：
Hoopfer, Eric D.;Jung, Yonil;Anderson, David J.
通讯作者：
Anderson, David J.