Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels.
Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels.
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DOI：
10.1371/journal.pone.0053030
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Franzosi MG
中科院分区：
文献类型：
--
作者：
Barbati E;Specchia C;Villella M;Rossi ML;Barlera S;Bottazzi B;Crociati L;d'Arienzo C;Fanelli R;Garlanda C;Gori F;Mango R;Mantovani A;Merla G;Nicolis EB;Pietri S;Presbitero P;Sudo Y;Villella A;Franzosi MG
PTX 3是先天免疫系统的长五聚体，由炎症部位的不同细胞类型（单核吞噬细胞、树突细胞、成纤维细胞和内皮细胞）产生。它似乎通过作用于心血管系统中的免疫-炎症平衡而具有心血管保护功能。PTX 3血浆浓度是急性心肌梗死（AMI）患者死亡率的独立预测因子，但PTX 3遗传变异对PTX 3血浆浓度的影响研究甚少，也没有关于PTX 3变异与AMI之间相关性的信息。欧洲血统的受试者（3245例，1751例AMI幸存者和1494例对照）进行了三种常见PTX 3多态性（SNP）（rs 2305619，rs3816527，rs 1840680）的基因分型。比较两组人群中3个SNPs的基因型频率、等位基因频率和单倍型频率。所有基因型、等位基因和单倍型均与AMI的危险性无关。然而，调整年龄和性别的分析表明，三个PTX 3 SNP和相应的单倍型与不同的PTX 3血浆水平显着相关。在AMI患者中，PTX 3血浆浓度与3年全因死亡风险之间也存在显著相关性（OR 1.10，95% CI：1.01-1.20，p = 0.02）。 我们的研究表明，PTX 3血浆水平受到三种PTX 3多态性的影响。基因决定的高PTX 3水平不会影响AMI的风险，这表明PTX 3浓度本身甚至不太可能是AMI的一个温和的因果因素。分析还证实了PTX 3是AMI后的预后标志物。
PTX3 is a long pentraxin of the innate immune system produced by different cell types (mononuclear phagocytes, dendritic cells, fibroblasts and endothelial cells) at the inflammatory site. It appears to have a cardiovascular protective function by acting on the immune-inflammatory balance in the cardiovascular system. PTX3 plasma concentration is an independent predictor of mortality in patients with acute myocardial infarction (AMI) but the influence of PTX3 genetic variants on PTX3 plasma concentration has been investigated very little and there is no information on the association between PTX3 variations and AMI. Subjects of European origin (3245, 1751 AMI survivors and 1494 controls) were genotyped for three common PTX3 polymorphisms (SNPs) (rs2305619, rs3816527, rs1840680). Genotype and allele frequencies of the three SNPs and the haplotype frequencies were compared for the two groups. None of the genotypes, alleles or haplotypes were significantly associated with the risk of AMI. However, analysis adjusted for age and sex indicated that the three PTX3 SNPs and the corresponding haplotypes were significantly associated with different PTX3 plasma levels. There was also a significant association between PTX3 plasma concentrations and the risk of all-cause mortality at three years in AMI patients (OR 1.10, 95% CI: 1.01–1.20, p = 0.02). Our study showed that PTX3 plasma levels are influenced by three PTX3 polymorphisms. Genetically determined high PTX3 levels do not influence the risk of AMI, suggesting that the PTX3 concentration itself is unlikely to be even a modest causal factor for AMI. Analysis also confirmed that PTX3 is a prognostic marker after AMI.
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影响因子：
3.6
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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