Cytocompatibility evaluation of grafted IKVAV PLEOF hydrogels with bone marrow mesenchymal stem cells
Cytocompatibility evaluation of grafted IKVAV PLEOF hydrogels with bone marrow mesenchymal stem cells
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IKVAV PLEOF水凝胶与骨髓间充质干细胞移植的细胞相容性评价
DOI：
10.1007/s11595-014-1004-6
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Binbin Li, Ping Zhang, Yixia Yin [...] Yuan Tao,
中科院分区：
文献类型：
--
作者：
Binbin Li, Ping Zhang, Yixia Yin [...] Yuan Tao,
制备了新型水凝胶接枝IKVAV聚（丙交酯-co-环氧乙烷-co-富马酸酯）（PLEOF）水凝胶（GIPHs）。采用大鼠骨髓间充质干细胞（BMMSCs），通过细胞活力和细胞凋亡实验评价GIPH的细胞相容性。GIPH对BMMSCs增殖的影响呈浓度和时间依赖性。100 μg/mL GIPHs处理组BMMSCs的增殖能力在72 h时达到最大值，比对照组增加30.1%。GIPHs 100 μg/mL处理24 h后，凋亡细胞数与对照组相同。GIPH能够为BMMSCs的存活和增殖提供合适的环境。
The novel hydrogels-grafted IKVAV poly (lactide-co-ethylene oxide-co-fumarate) (PLEOF) hydrogels (GIPHs) were developed. The rat bone marrow mesenchymal stem cells (BMMSCs) were employed, and the cell vitality and apoptosis assays were carried out to evaluate the cytocomptibility of GIPHs. Our data demonstrated that the influence of GIPHs on the proliferation of BMMSCs was in a concentration and time dependent manner. The proliferative ability of BMMSCs in GIPHs-treated group (100 μg/mL) after 72 h presented a maximum response which was 30.1% more than that of control group. The numbers of apoptotic cells in GIPHs-treated group (100 μg/mL) were just as much as that of control group after 24 h treatment. The GIPHs are able to provide an appropriate environment for BMMSCs survival and proliferation.
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影响因子：
--
作者：
B. Johnstone;J. Yoo
通讯作者：
B. Johnstone;J. Yoo
影响因子：
2.9
作者：
F. Yokoyama;N. Suzuki;M. Haruki;N. Nishi;S. Oishi;N. Fujii;A. Utani;H. Kleinman;M. Nomizu
通讯作者：
F. Yokoyama;N. Suzuki;M. Haruki;N. Nishi;S. Oishi;N. Fujii;A. Utani;H. Kleinman;M. Nomizu
影响因子：
14
作者：
Gupta, D;Tator, CH;Shoichet, MS
通讯作者：
Shoichet, MS
影响因子：
2.6
作者：
A. Friedenstein;J. F. Gorskaja;N. Kulagina
通讯作者：
A. Friedenstein;J. F. Gorskaja;N. Kulagina
影响因子：
3.6
作者：
J. Marler;A. Guha;J. Rowley;R. Koka;David Mooney;J. Upton;J. Vacanti
通讯作者：
J. Marler;A. Guha;J. Rowley;R. Koka;David Mooney;J. Upton;J. Vacanti