Prevalence, severity, and predictors of fatigue in subjects with primary Sjögren's syndrome.
Prevalence, severity, and predictors of fatigue in subjects with primary Sjögren's syndrome.
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DOI：
10.1002/art.24311
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发表时间：
2008-12-15
影响因子：
--
通讯作者：
Moser, Kathy
中科院分区：
文献类型：
--
作者：
Segal, Barbara;Thomas, William;Rogers, Tyson;Leon, Joanlise M.;Hughes, Pamela;Patel, Danielle;Patel, Ketan;Novitzke, Jill;Rohrer, Michael;Gopalakrishnan, Rajaram;Myers, Sandra;Nazmul-Hossain, Abu;Emamian, Eshrat;Huang, Andrew;Rhodus, Nelson;Moser, Kathy
探讨原发性干燥综合征（PSS）患者疲劳程度与其他临床特征的关系，并确定导致疲劳的生理和心理因素。我们确定了94名符合美国-欧洲PSS分类共识标准的受试者。采用VAS、疲劳严重程度量表（FSS）和疲劳曲线（ProF）评估疲劳。使用多变量回归比较与疲劳的关联。67%的患者存在异常疲劳，定义为FSS评分大于或等于4。疼痛，无助和抑郁是最强的预测FSS和躯体疲劳领域的ProF（Prof-S），无论是调整和不调整生理和血清学特征。抑郁症与更高水平的疲劳有关;然而，大多数异常疲劳的患者并不抑郁。抗Ro/SSA阳性患者报告疲劳的可能性并不比血清阴性患者高。回归模型解释了FSS中62%的方差和Prof-S中78%的方差。精神疲劳与抑郁和无助相关，但该模型仅预测了精神疲劳方差的54%。心理社会变量是疲劳的决定因素，但只是部分原因。虽然疲劳与抑郁有关，抑郁不是PSS中疲劳的主要原因。需要调查疲劳的生理和心理方面的病理生理学相关性，以指导更有效的干预措施的发展。
To investigate the relationship of fatigue severity to other clinical features in primary Sjogren’s syndrome (PSS) and to identify factors contributing to the physical and mental aspects of fatigue. We identified 94 subjects who met the American-European consensus criteria for the classification of PSS. Fatigue was assessed with a VAS, the Fatigue Severity Scale (FSS) and the Profile of Fatigue (ProF.) Associations with fatigue was compared using multivariate regression. Abnormal fatigue defined as a FSS score of greater than or equal to 4 was present in 67% of the patients. Pain, helplessness and depression were the strongest predictors of both FSS and the somatic fatigue domain of the ProF (Prof-S), both with and without adjustment for physiologic and serologic characteristics. Depression was associated with higher levels of fatigue; however, the majority of patients with abnormal fatigue were not depressed. Anti-Ro/SSA positive patients were no more likely to report fatigue than seronegative patients. The regression models explained 62% of the variance in FSS and 78% of the variance in Prof-S. Mental fatigue was correlated with depression and helplessness, but the model predicted only 54% of the variance in mental fatigue (Prof-M.). Psychosocial variables are determinants of fatigue, but only partly account for it. While fatigue is associated with depression, depression is not the primary cause of fatigue in PSS. Investigation of the pathophysiologic correlates of physical and mental aspects of fatigue is needed to guide the development of more effective interventions.
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影响因子：
5.8
作者：
Flachenecker, P;Kümpfel, T;Toyka, K
通讯作者：
Toyka, K
影响因子：
6.2
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Dimeo, FC
通讯作者：
Dimeo, FC
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通讯作者：
Platts, RG
影响因子：
3.1
作者：
LANE, TJ;MATTHEWS, DA;MANU, P
通讯作者：
MANU, P