Brain-wide human oscillatory LFP activity during visual working memory.
Brain-wide human oscillatory LFP activity during visual working memory.
复制标题
视觉工作记忆期间全脑人类振荡 LFP 活动。
DOI：
10.1101/2023.09.06.556554
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Constantinidis,Christos
中科院分区：
文献类型：
--
作者：
Singh,Balbir;Wang,Zhengyang;Madiah,LeenM;Gatti,SElizabeth;Fulton,JennaN;Johnson,GrahamW;Li,Rui;Dawant,BenoitM;Englot,DarioJ;Bick,SarahK;Roberson,ShawniquaWilliams;Constantinidis,Christos
振荡活动被认为是认知过程的标志，尽管它在工作记忆过程中在大脑中的作用和分布一直存在争议。为了了解振荡活动如何区分人类的任务和大脑区域，我们记录了12名成年人在执行视觉空间和形状匹配记忆任务时的局部场电位（lfp）。任务的设计是在刺激传递和反应启动之间的一定延迟间隔内参与工作记忆过程。记录lfp使用植入的颅内深度电极来定位癫痫发作，用于治疗难治性癫痫。与任务相关的LFP功率分析显示，在视觉刺激呈现和工作记忆维持过程中，包括枕叶、顶叶、颞叶、岛叶和前额叶皮质区，以及包括杏仁核和海马体在内的皮层下结构在内的皮层区域网络被激活。在大多数大脑区域，刺激的出现产生宽带功率增加，而伽马功率在工作记忆任务的延迟间隔期间是明显的。不同区域间的显著差异包括，在500 ms视觉刺激呈现期间，枕叶皮层在高伽马（100-150 Hz）范围内的功率升高，而在其他区域则不太明显或不存在。在刺激呈现后，也观察到以β频率（16-40 Hz）为中心的能量下降，其幅度在不同区域有所不同。这些结果揭示了振荡活动在广泛网络中的相互作用，以及与视觉工作记忆相关的振荡过程的区域特异性特征。
Oscillatory activity is thought to be a marker of cognitive processes, although its role and distribution across the brain during working memory has been a matter of debate. To understand how oscillatory activity differentiates tasks and brain areas in humans, we recorded local field potentials (LFPs) in 12 adults as they performed visual-spatial and shape-matching memory tasks. Tasks were designed to engage working memory processes at a range of delay intervals between stimulus delivery and response initiation. LFPs were recorded using intracranial depth electrodes implanted to localize seizures for management of intractable epilepsy. Task-related LFP power analyses revealed an extensive network of cortical regions that were activated during the presentation of visual stimuli and during their maintenance in working memory, including occipital, parietal, temporal, insular, and prefrontal cortical areas, and subcortical structures including the amygdala and hippocampus. Across most brain areas, the appearance of a stimulus produced broadband power increase, while gamma power was evident during the delay interval of the working memory task. Notable differences between areas included that occipital cortex was characterized by elevated power in the high gamma (100–150 Hz) range during the 500 ms of visual stimulus presentation, which was less pronounced or absent in other areas. A decrease in power centered in beta frequency (16–40 Hz) was also observed after the stimulus presentation, whose magnitude differed across areas. These results reveal the interplay of oscillatory activity across a broad network, and region-specific signatures of oscillatory processes associated with visual working memory.
影响因子：
4.8
作者：
Owen, AM;McMillan, KM;Bullmore, ET
通讯作者：
Bullmore, ET
用于生物电活动量化的复杂解调技术的批判性评估。
DOI：
--
发表时间：
1977
期刊：
Biomedical sciences instrumentation
影响因子：
--
作者：
N. Papp;P. Ktonas
通讯作者：
P. Ktonas
DOI：
10.1073/pnas.95.13.7721
发表时间：
1998-06-23
影响因子：
11.1
作者：
Owen, AM;Stern, CE;Petrides, M
通讯作者：
Petrides, M