Electrochemical sensors for the detection of SARS-CoV-2 virus.
Electrochemical sensors for the detection of SARS-CoV-2 virus.
复制标题
DOI：
10.1016/j.cej.2021.132966
复制
发表时间：
2022-02-15
期刊：
影响因子：
--
通讯作者：
Aminabhavi TM
中科院分区：
文献类型：
--
作者：
Kumar N;Shetti NP;Jagannath S;Aminabhavi TM
冠状病毒（COVID-19）是一种致命的大流行病，已在全球蔓延，并造成了许多全球健康问题。尽管为早期发现和监测COVID-19不断开发其检测方法，但仍需要更多新颖的方法。目前使用的方法包括快速抗原检测、血清学调查、逆转录聚合酶链反应（RT-PCR）、基于人工智能的技术和基于传感器/生物传感器的分析。其中，RT-PCR检测具有较高的灵敏度和特异性，但检测时间较长，需要熟练的技术人员。最近，电化学传感器被开发出来，用于从患者的生物体液样本中快速监测和检测SARS-CoV-2。本文综述了近年来电化学传感器在病毒核酸、免疫球蛋白、抗原和整个病毒颗粒检测方面的研究进展。此外，我们还比较和评估了它们的检出限、灵敏度和特异性，以识别和监测COVID-19。此外，本文将讨论电化学传感器发展的最佳实践，如电极污垢，检测限制/定量测定和验证的限制。
Coronavirus (COVID-19), a deadly pandemic has spread worldwide and created many global health issues. Though methods of its detection are being continuously developed for the early detection and monitoring of COVID-19, still there is need for more novel methods. The presently used methods include rapid antigen tests, serological surveys, reverse transcription-polymerase chain reaction (RT-PCR), artificial intelligence-based techniques, and assays based on sensors/biosensors. Of all these, RT-PCR test has high sensitivity and specificity though it requires more time for testing and need for skilled technicians. Recently, electrochemical sensors have been developed for rapid monitoring and detection of SARS-CoV-2 from the patient’s biological fluid samples. This review covers the recently developed electrochemical sensors that are focused on the detection of viral nucleic acid, immunoglobulin, antigen, and the entire viral particles. In addition, we also compare and assess their detection limits, sensitivities and specificities for the identification and monitoring of COVID-19. Furthermore, this review will address the best practices for the development of electrochemical sensors such as electrode fouling, limit of detection/limit of quantification determination and verification.
登录
查看更多内容
DOI：
10.1073/pnas.2106724118
发表时间：
2021-07-27
影响因子：
11.1
作者：
de Lima LF;Ferreira AL;Torres MDT;de Araujo WR;de la Fuente-Nunez C
通讯作者：
de la Fuente-Nunez C
影响因子：
6.1
作者：
Abid SA;Ahmed Muneer A;Al-Kadmy IMS;Sattar AA;Beshbishy AM;Batiha GE;Hetta HF
通讯作者：
Hetta HF
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F
影响因子：
--
作者：
Abdelhamid HN;Badr G
通讯作者：
Badr G
影响因子：
--
作者：
Chandra, Pranjal
通讯作者：
Chandra, Pranjal