The association between IGF1 gene rs1520220 polymorphism and cancer susceptibility: a meta-analysis based on 12,884 cases and 58,304 controls.
The association between IGF1 gene rs1520220 polymorphism and cancer susceptibility: a meta-analysis based on 12,884 cases and 58,304 controls.
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IGF1基因rs1520220多态性与癌症易感性之间的关联：基于12,884例病例和58,304例对照的荟萃分析。
DOI：
10.1186/s12199-018-0727-y
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发表时间：
2018-08-16
影响因子：
4.7
通讯作者：
Wu LF
中科院分区：
文献类型：
--
作者：
Xu GP;Chen WX;Xie WY;Wu LF
胰岛素样生长因子1（IGF 1）基因中的rs 1520220多态性在几项研究中已被报道可影响癌症。然而，相关研究的结果并不一致。我们进行了一项荟萃分析，以调查rs 1520220和癌症之间的关联。检索了三个数据库（PubMed、Embase和Web of Science），以获得关于rs 1520220与癌症之间关系的研究。采用比值比（OR）和相关的95%置信区间（CI）来评估相关性的强度。根据癌症类型、种族和质量评分进行分层分析，当从不少于两项研究中获得结果时，将这些结果合并。rs 1520220与总体癌症风险之间没有正相关。然而，按种族分层的分析显示，rs 1520220显著增加了亚洲人群的癌症易感性。（等位基因模型OR = 1.10，95%CI = 1.00-1.21，p = 0.040;纯合子模型OR = 1.22，95%CI = 1.01-1.47，p = 0.040;优势模型OR = 1.19，95%CI = 1.01-1.39，p = 0.033）。在高加索人群中未检测到显著相关性。按癌症类型分层的分析表明，rs 1520220与乳腺癌易感性无关。我们的荟萃分析结果表明，IGF 1 rs 1520220在癌症易感性中的作用因种族和癌症类型而异，rs 1520220增加了亚洲人群的癌症易感性。本文的在线版本（10.1186/s12199-018-0727-y）包含补充材料，可供授权用户使用。
The rs1520220 polymorphism in the insulin-like growth factor 1 (IGF1) gene has been reported to affect cancer susceptibly in several studies. However, the results of the relevant studies are inconsistent. We conduct a current meta-analysis to investigate the association between rs1520220 and cancer susceptibly. Three databases (PubMed, Embase, and Web of Science) were searched for studies regarding the relationship between rs1520220 and cancer susceptibly. Odds ratios (ORs) and the related 95% confidence intervals (CIs) were employed to assess the strength of the associations. A stratified analysis was performed according to cancer type, ethnicity, and quality score, and when results were obtained from no fewer than two studies, these results were pooled. There was no positive association between rs1520220 and overall cancer risk. However, the analysis stratified by ethnicity revealed that rs1520220 significantly increased cancer susceptibility in Asian populations (allele model OR = 1.10, 95%Cl = 1.00–1.21, p = 0.040; homozygote model OR = 1.22, 95%Cl = 1.01–1.47, p = 0.040; dominant model OR = 1.19, 95%Cl = 1.01–1.39, p = 0.033). No significantly association was detected in Caucasian populations. The analysis stratified by cancer type suggested that rs1520220 was not associated with susceptibility to breast cancer. The results of our meta-analysis demonstrate that the role of IGF1 rs1520220 in cancer susceptibility varies by ethnicity and cancer type and that rs1520220 increases cancer susceptibility in Asian populations. The online version of this article (10.1186/s12199-018-0727-y) contains supplementary material, which is available to authorized users.
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影响因子：
2.3
作者：
Chokkalingam, Anand P.;Metayer, Catherine;Scelo, Ghislaine;Chang, Jeffrey S.;Schiffman, Joshua;Urayama, Kevin Y.;Ma, Xiaomei;Hansen, Helen M.;Feusner, James H.;Barcellos, Lisa F.;Wiencke, John K.;Wiemels, Joseph L.;Buffler, Patricia A.
通讯作者：
Buffler, Patricia A.
影响因子：
3.7
作者：
Ong J;Salomon J;te Morsche RH;Roelofs HM;Witteman BJ;Dura P;Lacko M;Peters WH
通讯作者：
Peters WH
影响因子：
3.8
作者：
Qian, Biyun;Zheng, Hong;Chen, Kexin
通讯作者：
Chen, Kexin
影响因子：
3.8
作者：
Lei, Haixin;Hemminki, Kari;Foersti, Asta
通讯作者：
Foersti, Asta
影响因子：
2.3
作者：
Matsuoka, Hiromichi;Makimura, Chihiro;Nakagawa, Kazuhiko
通讯作者：
Nakagawa, Kazuhiko